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Cellosaurus NK92-41BB (CVCL_B5ZF)

[Text version]
Cell line name NK92-41BB
Accession CVCL_B5ZF
Resource Identification Initiative To cite this cell line use: NK92-41BB (RRID:CVCL_B5ZF)
Comments Population: Caucasian.
Characteristics: Transfected with the CD16-CAR construct that consist of the signal peptide, the FCGR3/CD16A extracellular domain, the CD8A extracellular domain, the CD28 TM and co-activation domains, the 4-1BB co-activation domain and finally the CD247/CD3Z signaling domain.
Transfected with: HGNC; 3619; FCGR3A (extracellular domain).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Natural killer cell; CL=CL_0000623.
Disease Natural killer cell lymphoblastic leukemia/lymphoma (NCIt: C82217)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2142 (NK-92)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=34349345; DOI=10.1007/s10616-021-00476-1
Zhao H., Zhou Z.-L., Li G.-M., Liu G., Lin S.-Y., Chen W., Xiong S.
An NK cell line (NK92-41BB) expressing high levels of granzyme is engineered to express the high affinity chimeric genes CD16/CAR.
Cytotechnology 73:539-553(2021)

Cross-references
Encyclopedic resources Wikidata; Q112129460
Entry history
Entry creation17-Mar-2022
Last entry update05-Oct-2023
Version number5