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Cellosaurus CyT49 (CVCL_B850)

[Text version]

Cell line name CyT49
Synonyms VCYTe001-A
Accession CVCL_B850
Resource Identification Initiative To cite this cell line use: CyT49 (RRID:CVCL_B850)
Comments From: ViaCyte, Inc. (originally from CyThera, Novocell).
Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-10-0041.
Sequence variations Mutation; HGNC; 11998; TP53; Simple; p.Gly245Cys (c.733G>T); ClinVar=VCV000012349; Zygosity=Unspecified; Note=Somatic mutation acquired during proliferation (PubMed=28445466).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Blastocyst stage
Category Embryonic stem cell
STR profile Source(s): Novocell_2008_presentation_to_FDA

Markers:
CSF1PO11,12
D3S135816,17
D5S81810,11
D7S82010,12
D8S117912,16
D13S31711,12
D16S5399,12
D18S5112,18
D21S1128
FGA21,23
Penta E17,20
TH019.3
TPOX8,9
vWA16,17

Run an STR similarity search on this cell line
Web pages https://grants.nih.gov/stem_cells/registry/current.htm?id=187
https://discovery.lifemapsc.com/stem-cell-differentiation/in-vitro-cells/inner-cell-mass-homo-sapiens-cyt49-viacyte-novocell-san-diego-ca
Publications

PubMed=18288110; DOI=10.1038/nbt1393
Kroon E.J., Martinson L.A., Kadoya K., Bang A.G., Kelly O.G., Eliazer S., Young H.Y., Richardson M., Smart N.G., Cunningham J., Agulnick A.D., D'Amour K.A., Carpenter M.K., Baetge E.E.
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo.
Nat. Biotechnol. 26:443-452(2008)

PubMed=22623968; DOI=10.1371/journal.pone.0037004
Schulz T.C., Young H.Y., Agulnick A.D., Babin M.J., Baetge E.E., Bang A.G., Bhoumik A., Cepa I., Cesario R.M., Haakmeester C., Kadoya K., Kelly J.R., Kerr J., Martinson L.A., McLean A.B., Moorman M.A., Payne J.K., Richardson M., Ross K.G., Sherrer E.S., Song X.-H., Wilson A.Z., Brandon E.P., Green C.E., Kroon E.J., Kelly O.G., D'Amour K.A., Robins A.J.
A scalable system for production of functional pancreatic progenitors from human embryonic stem cells.
PLoS ONE 7:E37004-E37004(2012)

PubMed=28445466; DOI=10.1038/nature22312
Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C., Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G., Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A., Eggan K.C.
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.
Nature 545:229-233(2017)

Cross-references
Cell line databases/resources hPSCreg; VCYTe001-A
ISCR; 702
SKIP; SKIP002593
Biological sample resources BioSamples; SAMEA17469418
ENCODE; ENCBS882LFH
ENCODE; ENCBS976TXC
Encyclopedic resources Wikidata; Q54817112
Experimental variables resources EFO; EFO_0007073
Gene expression databases GEO; GSM1548607
GEO; GSM1548608
Entry history
Entry creation06-Jun-2012
Last entry update20-May-2021
Version number17