Home  |  Contact

Cellosaurus NOK-SI (CVCL_BW57)

[Text version]

Cell line name NOK-SI
Synonyms NOKSI; NOKsi; Normal Oral Keratinocytes-Spontaneously Immortalized
Accession CVCL_BW57
Resource Identification Initiative To cite this cell line use: NOK-SI (RRID:CVCL_BW57)
Comments Problematic cell line: Contaminated. Shown to be a HaCaT derivative (ICLAC). Originally thought to originate from normal oral keratinocytes from a female donor.
Part of: OPC-22 oral and pharyngeal cancer cell line panel.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00589.
Omics: Deep exome analysis.
Derived from sampling site: Back; skin; epidermis; keratinocyte.
Sequence variations TP53 p.His179Tyr (c.535C>T) (ClinVar=VCV000127815) (PubMed=25275298).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0038 (HaCaT)
Sex of cell Male
Age at sampling 62Y
Category Spontaneously immortalized cell line
STR profile Source(s): PubMed=25275298

Markers:
AmelogeninX
CSF1PO9,11
D3S135816
D5S81812
D7S8209,11
D8S117914
D13S31710,12
D16S5399,12
D18S5112
D21S1128,30.2
FGA24
Penta D11,13
Penta E7,12
TH019.3
TPOX11,12
vWA16,17

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v10_distribution.xlsx
Publications

PubMed=20463891; DOI=10.1371/journal.pone.0010503
Castilho R.M., Squarize C.H., Leelahavanichkul K., Zheng Y., Bugge T., Gutkind J.S.
Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice.
PLoS ONE 5:E10503-E10503(2010)

PubMed=25275298; DOI=10.18632/oncotarget.2417
Martin D., Abba M.C., Molinolo A.A., Vitale-Cross L., Wang Z., Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Oncotarget 5:8906-8923(2014)

Cross-references
Other Wikidata; Q54930891
Polymorphism and mutation databases Cosmic; 2296312
Entry history
Entry creation02-May-2016
Last entry update02-Jul-2020
Version number5