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Cellosaurus PC-6 (CVCL_C002)

Cell line name PC-6
Synonyms PC 6; PC6
Accession CVCL_C002
Resource Identification Initiative To cite this cell line use: PC-6 (RRID:CVCL_C002)
Comments From: Immuno-Biological Laboratories (IBL); Tokyo; Japan.
Population: Japanese.
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_ZZ74 (PC-6/ADM2-1)CVCL_ZZ79 (PC-6/AMR-OH)CVCL_ZZ75 (PC-6/CDDP2-7)
CVCL_ZZ76 (PC-6/CPT2-2)CVCL_ZZ73 (PC-6/FU23-26)CVCL_S850 (PC-6/SN2-5)
CVCL_S849 (PC-6/TAX1-1)CVCL_ZZ77 (PC-6/VCR29-9)CVCL_ZZ78 (PC-6/VP1-1)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=2982333
Terashima M., Inoue K., Mukaiyama T., Mitsui I., Ogawa M.
Enhanced cytotoxic effect of adriamycin and vincristine against PC-6 (human lung cancer cell line) and Hattori (human breast cancer cell line).
Gan To Kagaku Ryoho 12:343-347(1985)

PubMed=3731100
Hanai N., Shitara K., Yoshida H.
Generation of monoclonal antibodies against human lung squamous cell carcinoma and adenocarcinoma using mice rendered tolerant to normal human lung.
Cancer Res. 46:4438-4443(1986)

PubMed=9259410; DOI=10.1002/(SICI)1097-0215(19970807)72:4<680::AID-IJC21>3.0.CO;2-E
Joto N., Ishii M., Minami M., Kuga H., Mitsui I., Tohgo A.
DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant.
Int. J. Cancer 72:680-686(1997)

PubMed=10912951; DOI=10.1097/00001813-200006000-00005
Ishii M., Iwahana M., Mitsui I., Minami M., Imagawa S., Tohgo A., Ejima A.
Growth inhibitory effect of a new camptothecin analog, DX-8951f, on various drug-resistant sublines including BCRP-mediated camptothecin derivative-resistant variants derived from the human lung cancer cell line PC-6.
Anticancer Drugs 11:353-362(2000)

PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7
Yokoi S., Yasui K., Saito-Ohara F., Koshikawa K., Iizasa T., Fujisawa T., Terasaki T., Horii A., Takahashi T., Hirohashi S., Inazawa J.
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Am. J. Pathol. 161:207-216(2002)

PubMed=15185009; DOI=10.1007/s00262-004-0533-9
Yamaji H., Iizasa T., Koh E., Suzuki M., Otsuji M., Chang H., Motohashi S., Yokoi S., Hiroshima K., Tagawa M., Nakayama T., Fujisawa T.
Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer.
Cancer Immunol. Immunother. 53:786-792(2004)

PubMed=17237272; DOI=10.1158/1535-7163.MCT-06-0529
Oguri T., Bessho Y., Achiwa H., Ozasa H., Maeno K., Maeda H., Sato S., Ueda R.
MRP8/ABCC11 directly confers resistance to 5-fluorouracil.
Mol. Cancer Ther. 6:122-127(2007)

PubMed=17511773; DOI=10.1111/j.1349-7006.2007.00507.x
Fukuyama T., Ichiki Y., Yamada S., Shigematsu Y., Baba T., Nagata Y., Mizukami M., Sugaya M., Takenoyama M., Hanagiri T., Sugio K., Yasumoto K.
Cytokine production of lung cancer cell lines: correlation between their production and the inflammatory/immunological responses both in vivo and in vitro.
Cancer Sci. 98:1048-1054(2007)

PubMed=18445659; DOI=10.1158/1535-7163.MCT-07-2088
Oguri T., Ozasa H., Uemura T., Bessho Y., Miyazaki M., Maeno K., Maeda H., Sato S., Ueda R.
MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer.
Mol. Cancer Ther. 7:1150-1155(2008)

PubMed=21128075; DOI=10.1007/s00280-010-1533-4
Takakuwa O., Oguri T., Ozasa H., Uemura T., Kasai D., Miyazaki M., Maeno K., Sato S.
Over-expression of MDR1 in amrubicinol-resistant lung cancer cells.
Cancer Chemother. Pharmacol. 68:669-676(2011)

Cross-references
Cell line databases/resources CGH-DB; 105-1
CGH-DB; 9051-4
Chemistry resources ChEMBL-Cells; CHEMBL3307571
ChEMBL-Targets; CHEMBL614235
PubChem_Cell_line; CVCL_C002
Encyclopedic resources Wikidata; Q54938461
Experimental variables resources EFO; EFO_0002845
Polymorphism and mutation databases Cosmic; 1212199
Cosmic; 1571745
Entry history
Entry creation06-Jun-2012
Last entry update21-Mar-2023
Version number15