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Cellosaurus A2780 PTX(4) (CVCL_C0D6)

[Text version]
Cell line name A2780 PTX(4)
Synonyms A2780 PTX (4); A/4 PTX-63d; A/4PTX-63d
Accession CVCL_C0D6
Resource Identification Initiative To cite this cell line use: A2780 PTX(4) (RRID:CVCL_C0D6)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; 795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Children:
CVCL_C0D7 (A2780 PTX(8))
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Web pages https://portal.ichb.pl/commercialization-of-model-for-drug-resistant-cancer-cells/
Publications

Patent=PL420318A1
Szenajch J., Goralski M., Handschuh L., Siatkowski I., Szabelska-Beresewicz A., Swiercz A., Zyprych-Walczak J.
Human ovarian cancer cell culture model for paclitaxel-induced inverse resistance to paclitaxel and cisplatin and use thereof.
Patent number PL420318A1, 17-Jun-2019

PubMed=33287223; DOI=10.3390/ijms21239218
Szenajch J., Szabelska-Beresewicz A., Swiercz A., Zyprych-Walczak J., Siatkowski I., Goralski M., Synowiec A., Handschuh L.
Transcriptome remodeling in gradual development of inverse resistance between paclitaxel and cisplatin in ovarian cancer cells.
Int. J. Mol. Sci. 21:9218.1-9218.30(2020)

Cross-references
Cell line collections (Providers) CancerTools; 160729
Ximbio; 160729
Cell line databases/resources cancercelllines; CVCL_C0D6
Encyclopedic resources Wikidata; Q112927041
Gene expression databases GEO; GSM4845009
GEO; GSM4845010
Entry history
Entry creation23-Jun-2022
Last entry update05-Oct-2023
Version number5