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Cellosaurus PCI-06A (CVCL_C173)

[Text version]

Cell line name PCI-06A
Synonyms PCI-6A; PCI-6T; PCI-6.1
Accession CVCL_C173
Resource Identification Initiative To cite this cell line use: PCI-06A (RRID:CVCL_C173)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for RHOA p.Gly17Glu (c.50G>A) (CCLE; Cosmic-CLP).
Heterozygous for TP53 p.Arg175His (c.524G>A) and c.1101-2A>T; splice acceptor mutation (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.89
Native American0
East Asian, North1.02
East Asian, South0
South Asian0.59
European, North68.64
European, South28.85
Disease Tonsillar squamous cell carcinoma (NCIt: C8183)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_C174 ! PCI-06B
Sex of cell Male
Age at sampling 81Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP

Markers:
AmelogeninX
CSF1PO11
D5S81811
D7S8207,10
D13S31710,13,14
D16S53911,14
TH017,9.3
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=2766286
Heo D.S., Snyderman C.H., Gollin S.M., Pan S., Walker E., Deka R., Barnes E.L., Johnson J.T., Herberman R.B., Whiteside T.L.
Biology, cytogenetics, and sensitivity to immunological effector cells of new head and neck squamous cell carcinoma lines.
Cancer Res. 49:5167-5175(1989)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994)

PubMed=8084624; DOI=10.1177/01945998941113P105
Snyderman C.H., Klapan I., Milanovich M., Heo D.S., Wagner R., Schwartz D., Johnson J.T., Whiteside T.L.
Comparison of in vivo and in vitro prostaglandin E2 production by squamous cell carcinoma of the head and neck.
Otolaryngol. Head Neck Surg. 111:189-196(1994)

PubMed=14996750; DOI=10.1158/0008-5472.CAN-03-2968
Wang J., Xi L., Hunt J.L., Gooding W., Whiteside T.L., Chen Z., Godfrey T.E., Ferris R.L.
Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype.
Cancer Res. 64:1861-1866(2004)

PubMed=17312569; DOI=10.1002/hed.20478
Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L., Koch W.M., Ferris R.L., Lai S.Y.
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CCLE; PCI6A_UPPER_AERODIGESTIVE_TRACT
Cell_Model_Passport; SIDM00115
Cosmic-CLP; 1240206
DepMap; ACH-002298
GDSC; 1240206
Chemistry resources PharmacoDB; PCI6A_1254_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670345
Other Wikidata; Q54938652
Entry history
Entry creation06-Jun-2012
Last entry updated06-Sep-2019
Version number17