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Cellosaurus UPMM-3 (CVCL_C295)

[Text version]
Cell line name UPMM-3
Synonyms UPMM3; Uveal Primary Melanoma with Monosomy-3 3
Accession CVCL_C295
Resource Identification Initiative To cite this cell line use: UPMM-3 (RRID:CVCL_C295)
Comments Doubling time: 100 hours (PubMed=19212147).
Karyotypic information: Monosomy of chromosome 3 (PubMed=19212147).
Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.
Sequence variations
  • Mutation; HGNC; 4390; GNAQ; Simple; p.Gln209Pro (c.626A>C); ClinVar=VCV000375957; Zygosity=Unspecified (PubMed=22236444).
Disease Uveal melanoma (NCIt: C7712)
Uveal melanoma (ORDO: Orphanet_39044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ICLC; PubMed=22236444

Markers:
AmelogeninX,Y
CSF1PO12,13
D5S81810,11
D7S8208,11
D13S3178,11
D16S53912
D21S1128,31.2
FGA19
TH017,9.3
TPOX9,10
vWA16,17

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Publications

PubMed=19212147; DOI=10.1159/000201566
Nareyeck G., Zeschnigk M., Bornfeld N., Anastassiou G.
Novel cell lines derived by long-term culture of primary uveal melanomas.
Ophthalmologica 223:196-201(2009)

PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x
Griewank K.G., Yu X.-X., Khalili J., Sozen M.M., Stempke-Hale K., Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.
Genetic and molecular characterization of uveal melanoma cell lines.
Pigment Cell Melanoma Res. 25:182-187(2012)

PubMed=23849826; DOI=10.1016/j.ejca.2013.06.011
Amaro A., Mirisola V., Angelini G., Musso A., Tosetti F.I., Esposito A.I., Perri P., Lanza F.B., Nasciuti F., Mosci C., Puzone R., Salvi S., Truini M., Poggi A., Pfeffer U.
Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by Gefitinib and Cetuximab triggered antibody-dependent cellular cytotoxicity.
Eur. J. Cancer 49:3353-3365(2013)

Cross-references
Cell line collections (Providers) ICLC; HTL13001
Cell line databases/resources cancercelllines; CVCL_C295
CLDB; cl7223
Encyclopedic resources Wikidata; Q54991709
Polymorphism and mutation databases Cosmic; 1628401
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number16