Cellosaurus logo
expasy logo

Cellosaurus FM6 (CVCL_C581)

[Text version]
Cell line name FM6
Synonyms FM-6; FM 6
Accession CVCL_C581
Resource Identification Initiative To cite this cell line use: FM6 (RRID:CVCL_C581)
Comments Omics: Array-based CGH.
Derived from site: Metastatic; Not specified.
Sequence variations
HLA typing Source: PubMed=7656272
Class I
HLA-AA*01,02
HLA-BB*07,08

Source: PubMed=15592718
Class I
HLA-AA*01:01,02:01
HLA-BB*07:02,08:01
HLA-CC*07:01:01,07:02
Class II
HLA-DPDPB1*04:01,01:01:01
HLA-DQDQB1*06:02,02:01
HLA-DRDRB1*03:01:01,15:01
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC=13012409; ESTDAB=ESTDAB-019

Markers:
AmelogeninX,Y
CSF1PO11
D3S135814
D5S8189,13
D7S8209,10
D13S31712
D16S53911,12
FGA23,24
TH019,9.3
TPOX11,12
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=7656272; DOI=10.1007/BF01527402
Kirkin A.F., Petersen T.R., Olsen A.C., Li L., thor Straten P., Zeuthen J.
Generation of human-melanoma-specific T lymphocyte clones defining novel cytolytic targets with panels of newly established melanoma cell lines.
Cancer Immunol. Immunother. 41:71-81(1995)

PubMed=8968104
Bartkova J., Lukas J., Guldberg P., Alsner J., Kirkin A.F., Zeuthen J., Bartek J.
The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis.
Cancer Res. 56:5475-5483(1996)

PubMed=9288767
Guldberg P., thor Straten P., Birck A., Ahrenkiel V., Kirkin A.F., Zeuthen J.
Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.
Cancer Res. 57:3660-3663(1997)

PubMed=9688544; DOI=10.1016/S0014-5793(98)00603-6
Dzhandzhugazyan K.N., Kirkin A.F., thor Straten P., Zeuthen J.
Ecto-ATP diphosphohydrolase/CD39 is overexpressed in differentiated human melanomas.
FEBS Lett. 430:227-230(1998)

PubMed=15592718; DOI=10.1007/s00262-004-0561-5
Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello Osuna F., Dodi I.A., Lopez-Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G., Garrido F.
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=17260012; DOI=10.1038/sj.onc.1210252
Jonsson G., Dahl C., Staaf J., Sandberg T., Bendahl P.-O., Ringner M., Guldberg P., Borg A.
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Oncogene 26:4738-4748(2007)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L., Borg A., Pawelec G., Guldberg P.
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

PubMed=25728708; DOI=10.1111/pcmr.12364
Vogel C.J., Smit M.A., Maddalo G., Possik P.A., Sparidans R.W., van der Burg S.H., Verdegaal E.M.E., Heck A.J.R., Samatar A.A., Beijnen J.H., Altelaar A.F.M., Peeper D.S.
Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.
Pigment Cell Melanoma Res. 28:307-317(2015)

Cross-references
Cell line collections (Providers) ECACC; 13012409
Cell line databases/resources cancercelllines; CVCL_C581
ESTDAB; ESTDAB-019
Encyclopedic resources Wikidata; Q54835054
Gene expression databases GEO; GSM156021
Polymorphism and mutation databases Cosmic; 808554
Cosmic; 874437
Cosmic; 972278
Cosmic; 1047670
Cosmic; 2163772
Progenetix; CVCL_C581
Entry history
Entry creation22-Oct-2012
Last entry update02-May-2024
Version number24