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Cellosaurus FM74 (CVCL_C603)

[Text version]
Cell line name FM74
Synonyms FM-74
Accession CVCL_C603
Resource Identification Initiative To cite this cell line use: FM74 (RRID:CVCL_C603)
Comments Omics: Array-based CGH.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Unspecified (PubMed=17260012).
HLA typing Source: PubMed=15592718
Class I
HLA-AA*31:01:02,24:02
HLA-BB*15:01:01:01,35:01
HLA-CC*03:03,04:01:01
Class II
HLA-DPDPB1*04:01
HLA-DQDQB1*03:02,05:01
HLA-DRDRB1*01:01,04:01:01
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC=13012422; ESTDAB=ESTDAB-022

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135815,16
D5S81812,13 (ECACC=13012422)
13 (ESTDAB=ESTDAB-022)
D7S8208,9 (ECACC=13012422)
8,10 (ESTDAB=ESTDAB-022)
D13S3178,9 (ECACC=13012422)
12 (ESTDAB=ESTDAB-022)
D16S53912
FGA20,21
TH019.3
TPOX9,12
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=7656272; DOI=10.1007/BF01527402
Kirkin A.F., Petersen T.R., Olsen A.C., Li L., thor Straten P., Zeuthen J.
Generation of human-melanoma-specific T lymphocyte clones defining novel cytolytic targets with panels of newly established melanoma cell lines.
Cancer Immunol. Immunother. 41:71-81(1995)

PubMed=8968104
Bartkova J., Lukas J., Guldberg P., Alsner J., Kirkin A.F., Zeuthen J., Bartek J.
The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis.
Cancer Res. 56:5475-5483(1996)

PubMed=15592718; DOI=10.1007/s00262-004-0561-5
Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello Osuna F., Dodi I.A., Lopez-Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G., Garrido F.
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=17260012; DOI=10.1038/sj.onc.1210252
Jonsson G., Dahl C., Staaf J., Sandberg T., Bendahl P.-O., Ringner M., Guldberg P., Borg A.
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Oncogene 26:4738-4748(2007)

Cross-references
Cell line collections (Providers) ECACC; 13012422
Cell line databases/resources cancercelllines; CVCL_C603
ESTDAB; ESTDAB-022
Encyclopedic resources Wikidata; Q54835061
Gene expression databases GEO; GSM156015
Polymorphism and mutation databases Cosmic; 808559
Cosmic; 1047675
IARC_TP53; 26101
Progenetix; CVCL_C603
Entry history
Entry creation22-Oct-2012
Last entry update02-May-2024
Version number18