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Cellosaurus FM93/2 (CVCL_C617)

[Text version]
Cell line name FM93/2
Synonyms FM-93/2
Accession CVCL_C617
Resource Identification Initiative To cite this cell line use: FM93/2 (RRID:CVCL_C617)
Comments Omics: HLA class I peptidome analysis by proteomics.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23851445).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly266Arg (c.795_796GG>AA); Zygosity=Unspecified (PubMed=23851445).
HLA typing Source: PubMed=15592718
Class I
HLA-AA*02:01,26:01
HLA-BB*40:01,44:02
HLA-CC*03:04,05:01
Class II
HLA-DPDPB1*04:02,03:01:01
HLA-DQDQB1*03:01:01,05:01
HLA-DRDRB1*14:01:01,04:01:01
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9680 (FM93)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC; ESTDAB

Markers:
AmelogeninX
CSF1PO12,14
D3S135818
D5S81811,12
D7S8209
D13S31711
D16S53911,12
FGA20
TH019,9.3
TPOX9
vWA17 (ESTDAB)
17,18 (ECACC)

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Publications

PubMed=15592718; DOI=10.1007/s00262-004-0561-5
Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello F., Dodi I.A., Lopez Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G., Garrido F.
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L., Borg A., Pawelec G., Guldberg P.
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

PubMed=27600516; DOI=10.1007/s00262-016-1897-3
Gloger A., Ritz D., Fugmann T., Neri D.
Mass spectrometric analysis of the HLA class I peptidome of melanoma cell lines as a promising tool for the identification of putative tumor-associated HLA epitopes.
Cancer Immunol. Immunother. 65:1377-1393(2016)

Cross-references
Cell line collections (Providers) ECACC; 13012419
Cell line databases/resources cancercelllines; CVCL_C617
ESTDAB; ESTDAB-033
Encyclopedic resources Wikidata; Q54835076
Polymorphism and mutation databases Cosmic; 2163783
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number16