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Cellosaurus UKRV-Mel-22a (CVCL_C661)

[Text version]
Cell line name UKRV-Mel-22a
Accession CVCL_C661
Resource Identification Initiative To cite this cell line use: UKRV-Mel-22a (RRID:CVCL_C661)
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=23851445).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23348503; PubMed=23851445).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_C662 ! UKRV-Mel-22b
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ESTDAB

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135815,16
D5S81811,12
D7S8209
D13S3179,12
FGA21,24
TH019.3
TPOX8,11
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=23348503; DOI=10.1126/science.1230062
Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L., Borg A., Pawelec G., Guldberg P.
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C661
ESTDAB; ESTDAB-182
Encyclopedic resources Wikidata; Q54990618
Polymorphism and mutation databases Cosmic; 1846717
Cosmic; 2163860
Cosmic; 2686530
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number15