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Cellosaurus UKRV-Mel-22b (CVCL_C662)

[Text version]
Cell line name UKRV-Mel-22b
Synonyms UKRVMEL22b
Accession CVCL_C662
Resource Identification Initiative To cite this cell line use: UKRV-Mel-22b (RRID:CVCL_C662)
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Heterozygous (PubMed=26909863).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Heterozygous (PubMed=26909863).
  • Gene fusion; HGNC; 7413; MTAP + HGNC; 34341; CDKN2B-AS1; Name(s)=MTAP-ANRIL (PubMed=26909863).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23348503).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_C661 ! UKRV-Mel-22a
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ESTDAB

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135815,16
D5S81811,12
D7S820Not_detected
D13S3179,12
FGA24
TH019.3
TPOX8,11
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=19340423; DOI=10.1007/s00262-009-0701-z
Mendez R., Aptsiauri N., Del Campo A., Maleno I., Cabrera T., Ruiz-Cabello F., Garrido F., Garcia-Lora A.
HLA and melanoma: multiple alterations in HLA class I and II expression in human melanoma cell lines from ESTDAB cell bank.
Cancer Immunol. Immunother. 58:1507-1515(2009)

PubMed=23348503; DOI=10.1126/science.1230062
Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

PubMed=26909863; DOI=10.18632/oncotarget.7503
Xie H.-P., Rachakonda P.S., Heidenreich B., Nagore E., Sucker A., Hemminki K., Schadendorf D., Kumar R.
Mapping of deletion breakpoints at the CDKN2A locus in melanoma: detection of MTAP-ANRIL fusion transcripts.
Oncotarget 7:16490-16504(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C662
ESTDAB; ESTDAB-183
Encyclopedic resources Wikidata; Q54990619
Polymorphism and mutation databases Cosmic; 1846718
Cosmic; 2686531
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number14