Cellosaurus cell line PaCa 5061 (CVCL_C886)

• Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=20553613).
  
• Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=20553613).
  

PubMed=20553613; DOI=10.1186/1471-2407-10-295
Kalinina T., Gungor C., Thieltges S., Moller-Krull M., Murga Penas E.-M., Wicklein D., Streichert T., Schumacher U., Kalinin V., Simon R., Otto B., Dierlamm J., Schwarzenbach H., Effenberger K.E., Bockhorn M., Izbicki J.R., Yekebas E.F.
Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung.
BMC Cancer 10:295.1-295.13(2010)

PubMed=21632553; DOI=10.1158/0008-5472.CAN-11-0036
Gungor C., Zander H., Effenberger K.E., Vashist Y.K., Kalinina T., Izbicki J.R., Yekebas E.F., Bockhorn M.
Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer.
Cancer Res. 71:5009-5019(2011)

DOI=10.4172/2324-9293.1000104
Wagenhauser M.U., Ruckert F., Niedergethmann M., Grutzmann R., Saeger H.-D.
Distribution of characteristic mutations in native ductal adenocarcinoma of the pancreas and pancreatic cancer cell lines.
Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013)

PubMed=22490524; DOI=10.1136/gutjnl-2011-300629
Gebauer F., Wicklein D., Stubke K., Nehmann N., Schmidt A., Salamon J., Peldschus K., Nentwich M.F., Adam G., Tolstonog G.V., Bockhorn M., Izbicki J.R., Wagener C., Schumacher U.
Selectin binding is essential for peritoneal carcinomatosis in a xenograft model of human pancreatic adenocarcinoma in pfp--/rag2-- mice.
Gut 62:741-750(2013)