ID   MKL-2
AC   CVCL_D027
SY   Mkl-2; MKL2
DR   Cell_Model_Passport; SIDM01790
DR   Cosmic; 1693073
DR   Cosmic; 2273917
DR   DepMap; ACH-001123
DR   GDSC; 1333015
DR   PharmacoDB; MKL2_935_2019
DR   PRIDE; PXD008181
DR   Wikidata; Q54905817
RX   PubMed=1717086;
RX   PubMed=12209990;
RX   PubMed=20444890;
RX   PubMed=23085629;
RX   PubMed=23563200;
RX   PubMed=27121059;
RX   PubMed=29696010;
RX   PubMed=30873613;
RX   PubMed=31889939;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Virology: Contains 1.7 copies of the genome of MCPyV per haploid cell (PubMed=23085629).
CC   Doubling time: 5 days (PubMed=20444890); 3 days (PubMed=30873613).
CC   Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
CC   Omics: Array-based CGH.
CC   Omics: Deep quantitative proteome analysis.
ST   Source(s): PubMed=30873613
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 12,13
ST   D16S539: 10,12
ST   D18S51: 14,17
ST   D21S11: 28.2,31.2
ST   D3S1358: 17
ST   D5S818: 12,14
ST   D7S820: 10,13
ST   D8S1179: 11,13
ST   FGA: 19,26
ST   Penta D: 10,13
ST   Penta E: 11,13
ST   TH01: 7,8
ST   TPOX: 8,11
ST   vWA: 16,17
DI   NCIt; C9231; Merkel cell carcinoma
DI   ORDO; Orphanet_79140; Cutaneous neuroendocrine carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 21-03-23; Version: 17
//
RX   PubMed=1717086; DOI=10.1016/0169-6009(91)90088-H;
RA   Martin E.M.E., Gould V.E., Hoog A., Rosen S.T., Radosevich J.A.,
RA   Deftos L.J.;
RT   "Parathyroid hormone-related protein, chromogranin A, and calcitonin
RT   gene products in the neuroendocrine skin carcinoma cell lines MKL1 and
RT   MKL2.";
RL   Bone Miner. 14:113-120(1991).
//
RX   PubMed=12209990; DOI=10.1002/ijc.10591;
RA   Van Gele M., Leonard J.H., Van Roy N., Van Limbergen H., Van Belle S.,
RA   Cocquyt V., Salwen H.R., De Paepe A., Speleman F.;
RT   "Combined karyotyping, CGH and M-FISH analysis allows detailed
RT   characterization of unidentified chromosomal rearrangements in Merkel
RT   cell carcinoma.";
RL   Int. J. Cancer 101:137-145(2002).
//
RX   PubMed=20444890; DOI=10.1128/JVI.02400-09;
RA   Houben R., Shuda M., Weinkam R., Schrama D., Feng H.-C., Chang Y.,
RA   Moore P.S., Becker J.C.;
RT   "Merkel cell polyomavirus-infected Merkel cell carcinoma cells require
RT   expression of viral T antigens.";
RL   J. Virol. 84:7064-7072(2010).
//
RX   PubMed=23085629; DOI=10.1016/j.jviromet.2012.10.001;
RA   Guastafierro A., Feng H.-C., Thant M., Kirkwood J.M., Chang Y.,
RA   Moore P.S., Shuda M.;
RT   "Characterization of an early passage Merkel cell polyomavirus-positive
RT   Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma
RT   mice.";
RL   J. Virol. Methods 187:6-14(2013).
//
RX   PubMed=23563200; DOI=10.1038/jid.2013.169;
RA   Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.S.,
RA   Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.;
RT   "Mechanisms of p53 restriction in Merkel cell carcinoma cells are
RT   independent of the Merkel cell polyoma virus T antigens.";
RL   J. Invest. Dermatol. 133:2453-2460(2013).
//
RX   PubMed=27121059; DOI=10.18632/oncotarget.8793;
RA   Hesbacher S., Pfitzer L., Wiedorfer K., Angermeyer S., Borst A.,
RA   Haferkamp S., Scholz C.-J., Wobser M., Schrama D., Houben R.;
RT   "RB1 is the crucial target of the Merkel cell polyomavirus Large T
RT   antigen in Merkel cell carcinoma cells.";
RL   Oncotarget 7:32956-32968(2016).
//
RX   PubMed=29696010; DOI=10.3389/fmicb.2018.00713;
RA   Velasquez C., Amako Y., Harold A., Toptan T., Chang Y., Shuda M.;
RT   "Characterization of a Merkel cell polyomavirus-positive Merkel cell
RT   carcinoma cell line CVG-1.";
RL   Front. Microbiol. 9:713.1-713.10(2018).
//
RX   PubMed=30873613; DOI=10.1002/ijc.32280;
RA   Schrama D., Sarosi E.-M., Adam C., Ritter C., Kaemmerer U.,
RA   Klopocki E., Konig E.-M., Utikal J.S., Becker J.C., Houben R.;
RT   "Characterization of six Merkel cell polyomavirus-positive Merkel cell
RT   carcinoma cell lines: integration pattern suggest that large T antigen
RT   truncating events occur before or during integration.";
RL   Int. J. Cancer 145:1020-1032(2019).
//
RX   PubMed=31889939; DOI=10.1186/s12014-019-9263-z;
RA   Kotowski U., Erovic B.M., Schnoll J., Stanek V., Janik S., Steurer M.,
RA   Mitulovic G.;
RT   "Quantitative proteome analysis of Merkel cell carcinoma cell lines
RT   using SILAC.";
RL   Clin. Proteomics 16:42.1-42.13(2019).
//