ID   MKL-2
AC   CVCL_D027
SY   Mkl-2; MKL2
DR   Cosmic; 1693073
DR   Cosmic; 2273917
DR   DepMap; ACH-001123
DR   GDSC; 1333015
DR   PharmacoDB; MKL2_935_2019
DR   Wikidata; Q54905817
RX   PubMed=1717086;
RX   PubMed=12209990;
RX   PubMed=20444890;
RX   PubMed=23563200;
RX   PubMed=27121059;
RX   PubMed=29696010;
CC   Characteristics: Contains ~1 copy of the genome of MCPyV per haploid cell (PubMed=29696010).
CC   Doubling time: 5 days (PubMed=20444890).
CC   Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
DI   NCIt; C9231; Merkel cell carcinoma
DI   ORDO; Orphanet_79140; Cutaneous neuroendocrine carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 12-03-20; Version: 14
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RX   PubMed=1717086; DOI=10.1016/0169-6009(91)90088-H;
RA   Martin E.M.E., Gould V.E., Hoog A., Rosen S.T., Radosevich J.A.,
RA   Deftos L.J.;
RT   "Parathyroid hormone-related protein, chromogranin A, and calcitonin
RT   gene products in the neuroendocrine skin carcinoma cell lines MKL1 and
RT   MKL2.";
RL   Bone Miner. 14:113-120(1991).
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RX   PubMed=12209990; DOI=10.1002/ijc.10591;
RA   Van Gele M., Leonard J.H., Van Roy N., Van Limbergen H., Van Belle S.,
RA   Cocquyt V., Salwen H.R., De Paepe A., Speleman F.;
RT   "Combined karyotyping, CGH and M-FISH analysis allows detailed
RT   characterization of unidentified chromosomal rearrangements in Merkel
RT   cell carcinoma.";
RL   Int. J. Cancer 101:137-145(2002).
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RX   PubMed=20444890; DOI=10.1128/JVI.02400-09;
RA   Houben R., Shuda M., Weinkam R., Schrama D., Feng H., Chang Y.,
RA   Moore P.S., Becker J.C.;
RT   "Merkel cell polyomavirus-infected Merkel cell carcinoma cells require
RT   expression of viral T antigens.";
RL   J. Virol. 84:7064-7072(2010).
//
RX   PubMed=23563200; DOI=10.1038/jid.2013.169;
RA   Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.,
RA   Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.;
RT   "Mechanisms of p53 restriction in Merkel cell carcinoma cells are
RT   independent of the Merkel cell polyoma virus T antigens.";
RL   J. Invest. Dermatol. 133:2453-2460(2013).
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RX   PubMed=27121059; DOI=10.18632/oncotarget.8793;
RA   Hesbacher S., Pfitzer L., Wiedorfer K., Angermeyer S., Borst A.,
RA   Haferkamp S., Scholz C.-J., Wobser M., Schrama D., Houben R.;
RT   "RB1 is the crucial target of the Merkel cell polyomavirus Large T
RT   antigen in Merkel cell carcinoma cells.";
RL   Oncotarget 7:32956-32968(2016).
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RX   PubMed=29696010; DOI=10.3389/fmicb.2018.00713;
RA   Velasquez C., Amako Y., Harold A., Toptan T., Chang Y., Shuda M.;
RT   "Characterization of a Merkel cell polyomavirus-positive Merkel cell
RT   carcinoma cell line CVG-1.";
RL   Front. Microbiol. 9:713-713(2018).
//