ID   Co-115
AC   CVCL_D102
SY   CO-115; Co 115; CO115; Co115
DR   cancercelllines; CVCL_D102
DR   ColonAtlas; CO115
DR   Cosmic; 711254
DR   Cosmic; 887213
DR   Cosmic; 1057757
DR   Cosmic; 1132574
DR   Cosmic; 1303885
DR   Cosmic; 1479610
DR   Cosmic; 2036658
DR   GEO; GSM1448067
DR   GEO; GSM2549993
DR   MetaboLights; MTBLS227
DR   TOKU-E; 4097
DR   Wikidata; Q54813921
RX   PubMed=975046;
RX   PubMed=1389533;
RX   PubMed=3349466;
RX   PubMed=9000147;
RX   PubMed=9000572;
RX   PubMed=11414198;
RX   PubMed=11526487;
RX   PubMed=20570890;
RX   PubMed=24042735;
RX   PubMed=25926053;
RX   PubMed=25944804;
RX   PubMed=26537799;
RX   PubMed=28683746;
CC   Population: Caucasian.
CC   Characteristics: Established from a tumor implanted into a nude mice.
CC   Doubling time: ~36 hours (Note=At 26th passage) (PubMed=975046); 27.66 hours (PubMed=25944804).
CC   Microsatellite instability: Instable (MSI) (PubMed=9000147; PubMed=24042735; PubMed=25926053; PubMed=28683746).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=20570890; PubMed=24042735; PubMed=28683746).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Glu157Glyfs*23 (c.469dupG) (c.469_470insG); ClinVar=VCV000655856; Zygosity=Unspecified (PubMed=24042735; PubMed=28683746).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Unspecified (PubMed=24042735; PubMed=28683746).
CC   Omics: N-glycan profiling.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Miscellaneous: STR profile mentioned but not shown in PubMed=24042735; obtained by personal communication of Lind G.E.
CC   Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.
ST   Source(s): PubMed=24042735; PubMed=25926053
ST   Amelogenin: X
ST   CSF1PO: 11,12,13,14 (PubMed=25926053)
ST   CSF1PO: 11,13 (PubMed=24042735)
ST   D13S317: 12,16 (PubMed=25926053)
ST   D13S317: 13,16 (PubMed=24042735)
ST   D16S539: 10,11
ST   D18S51: 14,15
ST   D19S433: 10,14,15
ST   D21S11: 34.2,35 (PubMed=25926053)
ST   D21S11: 35,35.2 (PubMed=24042735)
ST   D2S1338: 22,25
ST   D3S1358: 13,15,16
ST   D5S818: 10,11 (PubMed=24042735)
ST   D5S818: 10,12 (PubMed=25926053)
ST   D7S820: 7 (PubMed=24042735)
ST   D7S820: 7,10.3 (PubMed=25926053)
ST   D8S1179: 11,12
ST   FGA: 19,21
ST   TH01: 9,9.3
ST   TPOX: 8,9 (PubMed=24042735)
ST   TPOX: 8,10 (PubMed=25926053)
ST   vWA: 15,20
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   77Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 05-10-23; Version: 28
//
RX   PubMed=975046;
RA   Carrel S., Sordat B., Merenda C.;
RT   "Establishment of a cell line (Co-115) from a human colon carcinoma
RT   transplanted into nude mice.";
RL   Cancer Res. 36:3978-3984(1976).
//
RX   PubMed=1389533; DOI=10.1016/0959-8049(92)90031-V;
RA   Lahm H., Petral-Malec D., Yilmaz-Ceyhan A., Fischer J.R.,
RA   Lorenzoni M., Givel J.-C., Odartchenko N.;
RT   "Growth stimulation of a human colorectal carcinoma cell line by
RT   interleukin-1 and -6 and antagonistic effects of transforming growth
RT   factor beta 1.";
RL   Eur. J. Cancer 28:1894-1899(1992).
//
RX   PubMed=3349466;
RA   Chantret I., Barbat A., Dussaulx E., Brattain M.G., Zweibaum A.;
RT   "Epithelial polarity, villin expression, and enterocytic
RT   differentiation of cultured human colon carcinoma cells: a survey of
RT   twenty cell lines.";
RL   Cancer Res. 48:1936-1942(1988).
//
RX   PubMed=9000147;
RA   Cottu P.H., Muzeau F., Estreicher A., Flejou J.-F., Iggo R.D.,
RA   Thomas G., Hamelin R.;
RT   "Inverse correlation between RER+ status and p53 mutation in
RT   colorectal cancer cell lines.";
RL   Oncogene 13:2727-2730(1996).
//
RX   PubMed=9000572;
RA   Hoang J.-M., Cottu P.H., Thuille B., Salmon R.J., Thomas G.,
RA   Hamelin R.;
RT   "BAT-26, an indicator of the replication error phenotype in colorectal
RT   cancers and cell lines.";
RL   Cancer Res. 57:300-303(1997).
//
RX   PubMed=11414198; DOI=10.1007/s004320000207;
RA   Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H.,
RA   Wolf E., Gabius H.-J.;
RT   "Comprehensive galectin fingerprinting in a panel of 61 human tumor
RT   cell lines by RT-PCR and its implications for diagnostic and
RT   therapeutic procedures.";
RL   J. Cancer Res. Clin. Oncol. 127:375-386(2001).
//
RX   PubMed=11526487; DOI=10.1038/sj.onc.1204611;
RA   Gayet J., Zhou X.-P., Duval A., Rolland S., Hoang J.-M., Cottu P.H.,
RA   Hamelin R.;
RT   "Extensive characterization of genetic alterations in a series of
RT   human colorectal cancer cell lines.";
RL   Oncogene 20:5025-5032(2001).
//
RX   PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192;
RA   Janakiraman M., Vakiani E., Zeng Z.-S., Pratilas C.A., Taylor B.S.,
RA   Chitale D., Halilovic E., Wilson M., Huberman K., Ricarte Filho J.C.M.,
RA   Persaud Y., Levine D.A., Fagin J.A., Jhanwar S.C., Mariadason J.M.,
RA   Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B.;
RT   "Genomic and biological characterization of exon 4 KRAS mutations in
RT   human cancer.";
RL   Cancer Res. 70:5901-5911(2010).
//
RX   PubMed=24042735; DOI=10.1038/oncsis.2013.35;
RA   Ahmed D., Eide P.W., Eilertsen I.A., Danielsen S.A., Eknaes M.,
RA   Hektoen M., Lind G.E., Lothe R.A.;
RT   "Epigenetic and genetic features of 24 colon cancer cell lines.";
RL   Oncogenesis 2:e71.1-e71.8(2013).
//
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G.,
RA   Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S.,
RA   Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M.,
RA   Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.;
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002.1-7002.10(2015).
//
RX   PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457;
RA   Bazzocco S., Dopeso H., Carton-Garcia F., Macaya I., Andretta E.,
RA   Chionh F., Rodrigues P., Garrido M., Alazzouzi H., Nieto R.,
RA   Sanchez A., Schwartz S. Jr., Bilic J., Mariadason J.M., Arango D.;
RT   "Highly expressed genes in rapidly proliferating tumor cells as new
RT   targets for colorectal cancer treatment.";
RL   Clin. Cancer Res. 21:3695-3704(2015).
//
RX   PubMed=26537799; DOI=10.1074/mcp.M115.051235;
RA   Holst S., Deuss A.J.M., van Pelt G.W., van Vliet S.J.,
RA   Garcia-Vallejo J.J., Koeleman C.A.M., Deelder A.M., Mesker W.E.,
RA   Tollenaar R.A., Rombouts Y., Wuhrer M.;
RT   "N-glycosylation profiling of colorectal cancer cell lines reveals
RT   association of fucosylation with differentiation and caudal type
RT   homebox 1 (CDX1)/villin mRNA expression.";
RL   Mol. Cell. Proteomics 15:124-140(2016).
//
RX   PubMed=28683746; DOI=10.1186/s12943-017-0691-y;
RA   Berg K.C.G., Eide P.W., Eilertsen I.A., Johannessen B., Bruun J.,
RA   Danielsen S.A., Bjornslett M., Meza-Zepeda L.A., Eknaes M., Lind G.E.,
RA   Myklebost O., Skotheim R.I., Sveen A., Lothe R.A.;
RT   "Multi-omics of 34 colorectal cancer cell lines -- a resource for
RT   biomedical studies.";
RL   Mol. Cancer 16:116.1-116.16(2017).
//