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Cellosaurus KT-1 [Human leukemia] (CVCL_D200)

[Text version]
Cell line name KT-1 [Human leukemia]
Synonyms KT1
Accession CVCL_D200
Resource Identification Initiative To cite this cell line use: KT-1 [Human leukemia] (RRID:CVCL_D200)
Comments Population: Japanese.
Characteristics: Sensitive to the antiproliferative and apoptosis-inducing effects of IFN-alpha.
Doubling time: 18-24 hours (PubMed=9427720).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=9427720; PubMed=10071072).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_JH29 (KT-1/A3)CVCL_JH30 (KT-1/B7)
Sex of cell Male
Age at sampling 32Y
Category Cancer cell line
Publications

PubMed=9427720; DOI=10.1182/blood.V91.2.641
Yanagisawa K., Yamauchi H., Kaneko M., Kohno H., Hasegawa H., Fujita S.
Suppression of cell proliferation and the expression of a bcr-abl fusion gene and apoptotic cell death in a new human chronic myelogenous leukemia cell line, KT-1, by interferon-alpha.
Blood 91:641-648(1998)

PubMed=10071072; DOI=10.1016/s0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=11111114; DOI=10.1159/000041061
Yamauchi H., Sakai I., Narumi H., Soga S., Fujita S.
Sensitivity to interferon-alpha and interferon-stimulated gene factor 3 binding activity in human chronic myelogenous leukemia cell line KT-1.
Acta Haematol. 104:1-9(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

Cross-references
Encyclopedic resources Wikidata; Q54900516
Entry history
Entry creation22-Oct-2012
Last entry update29-Jun-2023
Version number15