ID   LiM6
AC   CVCL_D240
SY   LIM6; LiM-6; LS-LiM6; Ls-LiM6; LS LiM 6; LS LiM6; LSLiM6
DR   BTO; BTO:0004866
DR   cancercelllines; CVCL_D240
DR   Cosmic; 1132697
DR   Wikidata; Q54902542
RX   PubMed=1999484;
RX   PubMed=3032811;
RX   PubMed=21941373;
CC   Population: Caucasian.
CC   Characteristics: Has high liver-metastasizing ability during cecal growth, was established from parent cell line by serially selecting cells which metastasized from cecum to liver (PubMed=1999484).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1384 ! LS174T
SX   Female
AG   58Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 05-10-23; Version: 18
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RX   PubMed=1999484; DOI=10.1172/JCI115063;
RA   Bresalier R.S., Niv Y., Byrd J.C., Duh Q.-Y., Toribara N.W.,
RA   Rockwell R.W., Dahiya R., Kim Y.S.;
RT   "Mucin production by human colonic carcinoma cells correlates with
RT   their metastatic potential in animal models of colon cancer
RT   metastasis.";
RL   J. Clin. Invest. 87:1037-1045(1991).
//
RX   PubMed=3032811; DOI=10.1002/ijc.2910390514;
RA   Bresalier R.S., Raper S.E., Hujanen E.S., Kim Y.S.;
RT   "A new animal model for human colon cancer metastasis.";
RL   Int. J. Cancer 39:625-630(1987).
//
RX   PubMed=21941373; DOI=10.1038/cdd.2011.123;
RA   Mazurek N., Byrd J.C., Sun Y., Hafley M., Ramirez K., Burks J.,
RA   Bresalier R.S.;
RT   "Cell-surface galectin-3 confers resistance to TRAIL by impeding
RT   trafficking of death receptors in metastatic colon adenocarcinoma
RT   cells.";
RL   Cell Death Differ. 19:523-533(2012).
//