ID   MDA-MB-231-luc-D3H2LN
AC   CVCL_D257
SY   D3H2LN
DR   cancercelllines; CVCL_D257
DR   PerkinElmer; 119369
DR   Wikidata; Q54904599
RX   PubMed=15987449;
WW   https://web.archive.org/web/20150202002416/http://www.perkinelmer.com/catalog/product/id/119369
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Characteristics: Expression of firefly luciferase is under the control of a SV40 promoter (PerkinElmer=119369).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Transfected with: UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
CC   Discontinued: PerkinElmer; 119369; true.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1D88 ! MDA-MB-231-luc-D3H1
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 30-01-24; Version: 26
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RX   PubMed=15987449; DOI=10.1186/bcr1026;
RA   Jenkins D.E., Hornig Y.S., Oei Y.A., Dusich J.M., Purchio T.;
RT   "Bioluminescent human breast cancer cell lines that permit rapid and
RT   sensitive in vivo detection of mammary tumors and multiple metastases
RT   in immune deficient mice.";
RL   Breast Cancer Res. 7:R444-R454(2005).
//