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Cellosaurus MDA-MB-231-luc2 (CVCL_D582)

[Text version]

Cell line name MDA-MB-231-luc2
Synonyms MDA-MB-231-Luc2
Accession CVCL_D582
Resource Identification Initiative To cite this cell line use: MDA-MB-231-luc2 (RRID:CVCL_D582)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Transfected with: UniProtKB; P08659; Firefly luciferase (with optimized codon usage for mammalian expression).
Discontinued: PerkinElmer/Caliper; Catalog number 124319.
Sequence variations Heterozygous for BRAF p.Gly464Val (c.1391G>T) (ClinVar=VCV000040364) (from parent cell line).
Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (ClinVar=VCV000012580) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Homozygous for TP53 p.Arg280Lys (c.839G>A) (ClinVar=VCV000376657) (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Children:
CVCL_1D89 (MDA-MB-231-luc2-GFP)CVCL_1D92 (MDA-MB-231-luc2-LN)CVCL_1D90 (MDA-MB-231-luc2-tdTomato)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

DOI=10.1158/1538-7445.AM2013-3908
Kim J.B., Wong K., Urban K.
Generation of invasive breast cancer cell lines for in vivo imaging.
Cancer Res. 73 Suppl. 1:3908-3908(2013)

Cross-references
Ontologies BTO; BTO:0005172
Other Wikidata; Q54904600
Entry history
Entry creation22-Oct-2012
Last entry update02-Jul-2020
Version number16