ID   SK-9
AC   CVCL_D593
SY   SK9
DR   cancercelllines; CVCL_D593
DR   Wikidata; Q54953597
RX   PubMed=20471447;
RX   PubMed=29786757;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Doubling time: ~48 hours (PubMed=20471447).
CC   Sequence variation: Mutation; HGNC; 76; ABL1; Simple; p.Thr315Ile (c.944C>T) (c.1001C>T); ClinVar=VCV000012624; Zygosity=Unspecified (PubMed=20471447).
CC   Sequence variation: Mutation; HGNC; 12766; NSD2; Simple; p.Lys361Gln (c.1081A>C); ClinVar=VCV001088249; Zygosity=Heterozygous (PubMed=35124168).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C114819; Adult B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1
DI   ORDO; Orphanet_585909; B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 30-01-24; Version: 14
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RX   PubMed=20471447; DOI=10.1016/j.exphem.2010.04.017;
RA   Okabe S., Tauchi T., Ohyashiki K.;
RT   "Establishment of a new Philadelphia chromosome-positive acute
RT   lymphoblastic leukemia cell line (SK-9) with T315I mutation.";
RL   Exp. Hematol. 38:765-772(2010).
//
RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H.,
RA   Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T.,
RA   Sugita K., Hosoi H.;
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//