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Cellosaurus JJ012 (CVCL_D605)

[Text version]

Cell line name JJ012
Synonyms JJO12; JJ
Accession CVCL_D605
Resource Identification Initiative To cite this cell line use: JJ012 (RRID:CVCL_D605)
Comments Doubling time: 0.9 day (PubMed=12168675).
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Sequence variations Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=19787792).
Mutation; HGNC; 5382; IDH1; Simple; p.Arg132Gly (c.394C>G); ClinVar=VCV000375892; Zygosity=Heterozygous (PubMed=22057234; PubMed=26368816).
Mutation; HGNC; 11998; TP53; Simple; p.Gly199Val (c.596G>T); ClinVar=VCV000451799; Zygosity=Unspecified (PubMed=19787792).
Disease Primary central chondrosarcoma (NCIt: C7155)
Chondrosarcoma (ORDO: Orphanet_55880)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D901 (JJ012-TS4)
Sex of cell Male
Age at sampling 39Y
Category Cancer cell line
STR profile Source(s): PubMed=19787792; PubMed=25877200

AmelogeninX (PubMed=25877200)
X,Y (PubMed=19787792)
D3S135815,16,17,18 (PubMed=25877200)
16,17 (PubMed=19787792)
D18S5115 (PubMed=25877200)
15,17 (PubMed=19787792)
Penta D11,13
Penta E7,15
vWA15,16 (PubMed=25877200)
15,19 (PubMed=19787792)

Run an STR similarity search on this cell line

PubMed=8689637; DOI=10.1016/0304-3835(96)04274-7
Jagasia A.A., Block J.A., Qureshi A., Diaz M.O., Nobori T., Gitelis S., Iyer A.P.
Chromosome 9 related aberrations and deletions of the CDKN2 and MTS2 putative tumor suppressor genes in human chondrosarcomas.
Cancer Lett. 105:91-103(1996)

PubMed=10906887; DOI=10.1097/00003086-200007000-00038
Scully S.P., Berend K.R., Toth A., Qi W.-N., Qi Z., Block J.A.
Interstitial collagenase gene expression correlates with in vitro invasion in human chondrosarcoma.
Clin. Orthop. Relat. Res. 376:291-303(2000)

PubMed=12168675; DOI=10.1016/S0736-0266(01)00172-3
Ghert M.A., Qi W.-N., Erickson H.P., Block J.A., Scully S.P.
Tenascin-C expression and distribution in cultured human chondrocytes and chondrosarcoma cells.
J. Orthop. Res. 20:834-841(2002)

PubMed=19787792; DOI=10.1002/gcc.20717
Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S., Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H., Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W., Buerger H., Aigner T., Gabbert H.E., Poremba C.
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=22057234; DOI=10.1038/ng.1004
Pansuriya T.C., van Eijk R., d'Adamo P., van Ruler M.A.J.H., Kuijjer M.L., Oosting J., Cleton-Jansen A.-M., van Oosterwijk J.G., Verbeke S.L.J., Meijer D., van Wezel T., Nord K.H., Sangiorgi L., Toker B., Liegl-Atzwanger B., San-Julian M., Sciot R., Limaye N., Kindblom L.-G., Daugaard S., Godfraind C., Boon L.M., Vikkula M., Kurek K.C., Szuhai K., French P.J., Bovee J.V.M.G.
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome.
Nat. Genet. 43:1256-1261(2011)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26368816; DOI=10.1371/journal.pone.0133813
Li L., Paz A.C., Wilky B.A., Johnson B., Galoian K., Rosenberg A., Hu G., Tinoco G., Bodamer O.A., Trent J.C.
Treatment with a small molecule mutant IDH1 inhibitor suppresses tumorigenic activity and decreases production of the oncometabolite 2-hydroxyglutarate in human chondrosarcoma cells.
PLoS ONE 10:E0133813-E0133813(2015)

Ontologies BTO; BTO:0005168
EFO; EFO_0006604
Biological sample resources BioSample; SAMN03470880
Chemistry resources PharmacoDB; JJ012_705_2019
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM1676351
GEO; GSM1701681
Other Wikidata; Q54898950
Polymorphism and mutation databases Cosmic; 1602476
Cosmic; 1992323
IARC_TP53; 27035
Entry history
Entry creation22-Oct-2012
Last entry update20-May-2021
Version number23