ID   SK-OV-3/CBP
AC   CVCL_D621
SY   SKOV3/CBP; S-car
DR   cancercelllines; CVCL_D621
DR   Wikidata; Q54954499
RX   PubMed=15254775;
RX   PubMed=17269733;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:31355; Carboplatin (CBP; Paraplatin).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C7978; Ovarian serous cystadenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0532 ! SK-OV-3
SX   Female
AG   64Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 05-10-23; Version: 22
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RX   PubMed=15254775; DOI=10.3892/ijmm.14.2.257;
RA   Li L., Luan Y.-Z., Wang G.-D., Tang B.-J., Li D.-R., Zhang W.,
RA   Li X.-P., Zhao J.-S., Ding H., Reed E., Li Q.-D.Q.;
RT   "Development and characterization of five cell models for
RT   chemoresistance studies of human ovarian carcinoma.";
RL   Int. J. Mol. Med. 14:257-264(2004).
//
RX   PubMed=17269733; DOI=10.1021/pr060402r;
RA   Yan X.-D., Pan L.-Y., Yuan Y., Lang J.-H., Mao N.;
RT   "Identification of platinum-resistance associated proteins through
RT   proteomic analysis of human ovarian cancer cells and their
RT   platinum-resistant sublines.";
RL   J. Proteome Res. 6:772-780(2007).
//