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Cellosaurus PC-9/ER3 (CVCL_D726)

[Text version]

Cell line name PC-9/ER3
Synonyms PC-9-ER3
Accession CVCL_D726
Resource Identification Initiative To cite this cell line use: PC-9/ER3 (RRID:CVCL_D726)
Comments Selected for resistance to: ChEBI; CHEBI:114785; Erlotinib.
Sequence variations EGFR p.Glu746_Ala750del (c.2235_2249del15) (from parent cell line).
Homozygous for TP53 p.Arg248Gln (c.743G>A) (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=22712764; DOI=10.1111/j.1349-7006.2012.02363.x
Harada D., Takigawa N., Ochi N., Ninomiya T., Yasugi M., Kubo T., Takeda H., Ichihara E., Ohashi K., Takata S., Tanimoto M., Kiura K.
JAK2-related pathway induces acquired erlotinib resistance in lung cancer cells harboring an epidermal growth factor receptor-activating mutation.
Cancer Sci. 103:1795-1802(2012)

Cross-references
Other Wikidata; Q54938491
Polymorphism and mutation databases Cosmic; 1745415
Entry history
Entry creation22-Oct-2012
Last entry updated06-Sep-2019
Version number11