Home  |  Contact

Cellosaurus 11-18-GEF10-1 (CVCL_D776)

[Text version]
Cell line name 11-18-GEF10-1
Synonyms 11-18/GEF10-1
Accession CVCL_D776
Resource Identification Initiative To cite this cell line use: 11-18-GEF10-1 (RRID:CVCL_D776)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6659 (11-18)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=22815900; DOI=10.1371/journal.pone.0041017
Tabara K., Kanda R., Sonoda K., Kubo T., Murakami Y., Kawahara A., Azuma K., Abe H., Kage M., Yoshinaga A., Tahira T., Hayashi K., Arao T., Nishio K., Rosell R., Kuwano M., Ono M.
Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells.
PLoS ONE 7:E41017-E41017(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D776
Encyclopedic resources Wikidata; Q54554910
Polymorphism and mutation databases Cosmic; 1731375
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number14