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Cellosaurus PC-9/ER1 (CVCL_D778)

[Text version]
Cell line name PC-9/ER1
Synonyms PC-9-ER1; PC9-ER1
Accession CVCL_D778
Resource Identification Initiative To cite this cell line use: PC-9/ER1 (RRID:CVCL_D778)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:114785; Erlotinib.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=22815900; DOI=10.1371/journal.pone.0041017
Tabara K., Kanda R., Sonoda K., Kubo T., Murakami Y., Kawahara A., Azuma K., Abe H., Kage M., Yoshinaga A., Tahira T., Hayashi K., Arao T., Nishio K., Rosell R., Kuwano M., Ono M.
Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells.
PLoS ONE 7:E41017-E41017(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D778
Encyclopedic resources Wikidata; Q54938489
Polymorphism and mutation databases Cosmic; 1731371
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number19