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Cellosaurus PC-9/ER1 (CVCL_D778)

[Text version]

Cell line name PC-9/ER1
Synonyms PC-9-ER1; PC9-ER1
Accession CVCL_D778
Resource Identification Initiative To cite this cell line use: PC-9/ER1 (RRID:CVCL_D778)
Comments Selected for resistance to: ChEBI; CHEBI:114785; Erlotinib.
Sequence variations EGFR p.Glu746_Ala750del (c.2235_2249del15) (from parent cell line).
Homozygous for TP53 p.Arg248Gln (c.743G>A) (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line

PubMed=22815900; DOI=10.1371/journal.pone.0041017
Tabara K., Kanda R., Sonoda K., Kubo T., Murakami Y., Kawahara A., Azuma K., Abe H., Kage M., Yoshinaga A., Tahira T., Hayashi K., Arao T., Nishio K., Rosell R., Kuwano M., Ono M.
Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells.
PLoS ONE 7:E41017-E41017(2012)

Other Wikidata; Q54938489
Polymorphism and mutation databases Cosmic; 1731371
Entry history
Entry creation22-Oct-2012
Last entry updated06-Sep-2019
Version number12