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Cellosaurus KM20L2 (CVCL_D889)

[Text version]
Cell line name KM20L2
Synonyms KM-20L2; KM 20L2; KM 2012
Accession CVCL_D889
Resource Identification Initiative To cite this cell line use: KM20L2 (RRID:CVCL_D889)
Comments Problematic cell line: Contaminated. Shown to be a HT-29 derivative (PubMed=15703300; resulting in a decision not to include the cell line in the NCI60 panel).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00514.
Population: Caucasian.
Misspelling: KM202L; Note=Occasionally.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
Publications

PubMed=3349467
Morikawa K., Walker S.M., Jessup J.M., Fidler I.J.
In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice.
Cancer Res. 48:1943-1948(1988)

PubMed=2041050; DOI=10.1093/jnci/83.11.757
Monks A., Scudiero D.A., Skehan P., Shoemaker R.H., Paull K.D., Vistica D.T., Hose C.D., Langley J., Cronise P., Vaigro-Wolff A., Gray-Goodrich M., Campbell H., Mayo J.G., Boyd M.R.
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
J. Natl. Cancer Inst. 83:757-766(1991)

PubMed=15703300; DOI=10.1073/pnas.0405578102
Roschke A.V., Lababidi S., Tonon G., Gehlhaus K.S., Bussey K.J., Weinstein J.N., Kirsch I.R.
Karyotypic 'state' as a potential determinant for anticancer drug discovery.
Proc. Natl. Acad. Sci. U.S.A. 102:2964-2969(2005)

Cross-references
Cell line collections (Providers) NCI-DTP; KM 20L2
Cell line databases/resources cancercelllines; CVCL_D889
Anatomy/cell type resources BTO; BTO:0005911
Biological sample resources BioSample; SAMN06481115
Chemistry resources ChEMBL-Cells; CHEMBL3307782
ChEMBL-Targets; CHEMBL614791
PubChem_Cell_line; CVCL_D889
Encyclopedic resources Wikidata; Q54900067
Polymorphism and mutation databases IARC_TP53; 28215
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number29