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Cellosaurus KM20L2 (CVCL_D889)

Cell line name KM20L2
Synonyms KM-20L2; KM 20L2; KM 2012
Accession CVCL_D889
Resource Identification Initiative To cite this cell line use: KM20L2 (RRID:CVCL_D889)
Comments Problematic cell line: Contaminated. Shown to be a HT-29 derivative (PubMed=15703300; resulting in a decision not to include the cell line in the NCI60 panel).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00514.
Misspelling: KM202L; Occasionally.
Sequence variations Heterozygous for APC p.Glu853Ter (c.2557G>T) and p.Thr1556fs*3 (c.4666_4667insA) (from parent cell line).
Heterozygous for BRAF p.Val600Glu (c.1799T>A) (from parent cell line).
Heterozygous for PIK3CA p.Pro449Thr (c.1345C>A) (from parent cell line).
Homozygous for SMAD4 p.Gln311Ter (c.931C>T) (from parent cell line).
Homozygous for TP53 p.Arg273His (c.818G>A) (from parent cell line).
Disease Rectosigmoid adenocarcinoma (NCIt: C43584)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
Publications

PubMed=3349467
Morikawa K., Walker S.M., Jessup J.M., Fidler I.J.
In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice.
Cancer Res. 48:1943-1948(1988)

PubMed=15703300; DOI=10.1073/pnas.0405578102
Roschke A.V., Lababidi S., Tonon G., Gehlhaus K.S., Bussey K., Weinstein J.N., Kirsch I.R.
Karyotypic 'state' as a potential determinant for anticancer drug discovery.
Proc. Natl. Acad. Sci. U.S.A. 102:2964-2969(2005)

Cross-references
Cell line collections NCI-DTP; KM 20L2
Ontologies BTO; BTO:0005911
Biological sample resources BioSample; SAMN06481115
Chemistry resources ChEMBL-Cells; CHEMBL3307782
ChEMBL-Targets; CHEMBL614791
Other Wikidata; Q54900067