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Cellosaurus OVCAR-3/TxT5 (CVCL_DA02)

[Text version]
Cell line name OVCAR-3/TxT5
Synonyms OVCAR-3TxT5
Accession CVCL_DA02
Resource Identification Initiative To cite this cell line use: OVCAR-3/TxT5 (RRID:CVCL_DA02)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:4672; Docetaxel anhydrous (Taxotere).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 8979; PIK3R1; Simple; c.1746-2A>T; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0465 (OVCAR-3)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
Publications

PubMed=16382445; DOI=10.1002/gcc.20300
Wang Y.C., Juric D., Francisco B., Yu R.X., Duran G.E., Chen G.K., Chen X., Sikic B.I.
Regional activation of chromosomal arm 7q with and without gene amplification in taxane-selected human ovarian cancer cell lines.
Genes Chromosomes Cancer 45:365-374(2006)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DA02
Encyclopedic resources Wikidata; Q54937009
Gene expression databases GEO; GSM95456
Polymorphism and mutation databases Progenetix; CVCL_DA02
Entry history
Entry creation13-Jul-2016
Last entry update05-Oct-2023
Version number12