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Cellosaurus H1L1.1c2 (CVCL_DC20)

[Text version]
Cell line name H1L1.1c2
Synonyms H1L1.1
Accession CVCL_DC20
Resource Identification Initiative To cite this cell line use: H1L1.1c2 (RRID:CVCL_DC20)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12286.
Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists.
Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs).
Transfected with: UniProtKB; P08659; Firefly luciferase.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Hepatocellular carcinoma of the mouse (NCIt: C38756)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57L.
Hierarchy Parent: CVCL_0328 (Hepa-1c1c7)
Sex of cell Female
Category Cancer cell line
Publications

PubMed=8812265; DOI=10.1006/faat.1996.0056
Garrison P.M., Tullis K., Aarts J.M.M.J.G., Brouwer A., Giesy J.P., Denison M.S.
Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals.
Fundam. Appl. Toxicol. 30:194-203(1996)

Patent=US5854010
Denison M.S., Brouwer A., Clark G.C.
Bioassay for detecting 2,3,7,8-tetrachlorodibenzo-para-dioxin and TCDD-like compounds and novel recombinant cell line useful therefor.
Patent number US5854010, 29-Dec-1998

PubMed=15096657; DOI=10.1002/biof.5520200102
Han D., Nagy S.R., Denison M.S.
Comparison of recombinant cell bioassays for the detection of Ah receptor agonists.
BioFactors 20:11-22(2004)

PubMed=18969542; DOI=10.1016/j.talanta.2004.05.032
Denison M.S., Zhao B., Baston D.S., Clark G.C., Murata H., Han D.
Recombinant cell bioassay systems for the detection and relative quantitation of halogenated dioxins and related chemicals.
Talanta 63:1123-1133(2004)

PubMed=21394221; DOI=10.1007/s11426-010-0142-8
Zhao B., Baston D.S., Khan E., Sorrentino C., Denison M.S.
Enhancing the response of CALUX and CAFLUX cell bioassays for quantitative detection of dioxin-like compounds.
Sci. China Chem. 53:1010-1016(2010)

Cross-references
Encyclopedic resources Wikidata; Q54871986
Entry history
Entry creation13-Jul-2016
Last entry update29-Jun-2023
Version number10