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Cellosaurus H4L7.5c2 (CVCL_DC28)

Cell line name H4L7.5c2
Accession CVCL_DC28
Resource Identification Initiative To cite this cell line use: H4L7.5c2 (RRID:CVCL_DC28)
Comments Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists.
Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs).
Transfected with: UniProtKB; P08659; Firefly luciferase.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Rat hepatocellular carcinoma (NCIt: C60416)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: AxC.
Hierarchy Parent: CVCL_0284 (H4-II-E)
Sex of cell Male
Category Cancer cell line
Publications

PubMed=26366531; DOI=10.1021/acs.est.5b02906
Brennan J.C., He G.-C., Tsutsumi T., Zhao J., Wirth E., Fulton M.H., Denison M.S.
Development of species-specific Ah receptor-responsive third generation CALUX cell lines with enhanced responsiveness and improved detection limits.
Environ. Sci. Technol. 49:11903-11912(2015)

Cross-references
Encyclopedic resources Wikidata; Q54872159
Entry history
Entry creation13-Jul-2016
Last entry update29-Jun-2023
Version number8