Home  |  Contact

Cellosaurus HG2L6.1c1 (CVCL_DC30)

[Text version]

Cell line name HG2L6.1c1
Accession CVCL_DC30
Resource Identification Initiative To cite this cell line use: HG2L6.1c1 (RRID:CVCL_DC30)
Comments Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists.
Characteristics: Acts through the activation of a luciferase gene under the control of dioxin-response elements (DREs).
Transfected with: UniProtKB; P08659; Firefly luciferase.
Sequence variations NRAS p.Gln61Leu (c.182A>T) (ClinVar=VCV000375874) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line

PubMed=26366531; DOI=10.1021/acs.est.5b02906
Brennan J.C., He G., Tsutsumi T., Zhao J., Wirth E., Fulton M.H., Denison M.S.
Development of species-specific Ah receptor-responsive third generation CALUX cell lines with enhanced responsiveness and improved detection limits.
Environ. Sci. Technol. 49:11903-11912(2015)

Other Wikidata; Q54885925
Entry history
Entry creation13-Jul-2016
Last entry update02-Jul-2020
Version number9