ID   HG2L7.5c1
DR   Wikidata; Q54885927
RX   PubMed=26366531;
CC   Population: Caucasian.
CC   Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists.
CC   Characteristics: Acts through the activation of a luciferase gene under the control of dioxin-response elements (DREs).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Derived from sampling site: Liver.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 20-05-21; Version: 12
RX   PubMed=26366531; DOI=10.1021/acs.est.5b02906;
RA   Brennan J.C., He G.-C., Tsutsumi T., Zhao J., Wirth E., Fulton M.H.,
RA   Denison M.S.;
RT   "Development of species-specific Ah receptor-responsive third
RT   generation CALUX cell lines with enhanced responsiveness and improved
RT   detection limits.";
RL   Environ. Sci. Technol. 49:11903-11912(2015).