Cell line name |
MCF-7.5C |
Synonyms |
MCF7:5C; MCF-7 clone 5C; 5C |
Accession |
CVCL_DC70 |
Resource Identification Initiative |
To cite this cell line use: MCF-7.5C (RRID:CVCL_DC70) |
Comments |
Population: Caucasian. Characteristics: Undergoes rapid and complete apoptosis in the presence of physiologic concentrations of 17-alpha-estradiol. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0031 (MCF-7) Children:
|
Sex of cell |
Female |
Age at sampling |
69Y |
Category |
Cancer cell line |
Publications | PubMed=1301400; DOI=10.1016/0303-7207(92)90104-E Jiang S.-Y., Wolf D.M., Yingling J.M., Chang C.-S., Jordan V.C. An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol. Mol. Cell. Endocrinol. 90:77-86(1992) PubMed=9242427 Levenson A.S., Jordan V.C. MCF-7: the first hormone-responsive breast cancer cell line. Cancer Res. 57:3071-3078(1997) PubMed=16333030; DOI=10.1093/jnci/dji400 Lewis J.S., Meeke K., Osipo C., Ross E.A., Kidawi N., Li T.-Y., Bell E., Chandel N.S., Jordan V.C. Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation. J. Natl. Cancer Inst. 97:1746-1759(2005) PubMed=32453591; DOI=10.1021/acs.jmedchem.0c00456 Li Y.-F., Zhao J., Gutgesell L.M., Shen Z.-N., Ratia K., Dye K., Dubrovskyi O., Zhao H.-P., Huang F., Tonetti D.A., Thatcher G.R.J., Xiong R. Novel pyrrolopyridone bromodomain and extra-terminal motif (BET) inhibitors effective in endocrine-resistant ER+ breast cancer with acquired resistance to fulvestrant and palbociclib. J. Med. Chem. 63:7186-7210(2020) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_DC70
|
Encyclopedic resources |
Wikidata; Q54904329
|
Entry history |
Entry creation | 13-Jul-2016 |
Last entry update | 05-Oct-2023 |
Version number | 13 |
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