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Cellosaurus HepAD79 (CVCL_DE23)

[Text version]

Cell line name HepAD79
Synonyms Hep AD79; HepG2-AD79; AD-79; AD79
Accession CVCL_DE23
Resource Identification Initiative To cite this cell line use: HepAD79 (RRID:CVCL_DE23)
Comments Population: Caucasian.
Characteristics: Inducibly expresses a lamivudine-resistant HBV genome under the control of a tet operator/CMV promoter. Upon removal of tetracycline the cell line produces viral RNA and secrete virus-like particles into the supernatant.
Derived from sampling site: Liver.
Sequence variations Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line

Ladner S.K., Miller T.J., Otto M.J., King R.W.
The hepatitis B virus M539V polymerase variation responsible for 3TC resistance also confers cross-resistance to other nucleoside analogues.
Antivir. Chem. Chemother. 9:65-72(1998)

Other Wikidata; Q54882831
Entry history
Entry creation13-Jul-2016
Last entry update20-May-2021
Version number11