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Cellosaurus MDA231-LM2-4142 (CVCL_DG21)

[Text version]

Cell line name MDA231-LM2-4142
Synonyms MDA 231-LM2-4142; MDA-MB-231 #4142; LM2-4142; 4142
Accession CVCL_DG21
Resource Identification Initiative To cite this cell line use: MDA231-LM2-4142 (RRID:CVCL_DG21)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Characteristics: Established from MDA231-TGL cell line after 3 passage in nude mice.
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Transfected with: UniProtKB; P08659; Firefly luciferase.
Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Sequence variations Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VR35 (MDA231-TGL)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line

PubMed=16049480; DOI=10.1038/nature03799
Minn A.J., Gupta G.P., Siegel P.M., Bos P.D., Shu W., Giri D.D., Viale A.J., Olshen A.B., Gerald W.L., Massague J.
Genes that mediate breast cancer metastasis to lung.
Nature 436:518-524(2005)

Gene expression databases GEO; GSM50017
GEO; GSM587389
Other Wikidata; Q54904665
Entry history
Entry creation13-Jul-2016
Last entry update20-May-2021
Version number12