ID   MDA231-LM2-4142
AC   CVCL_DG21
SY   MDA 231-LM2-4142; MDA-MB-231 #4142; LM2-4142; 4142
DR   GEO; GSM50017
DR   GEO; GSM587389
DR   Wikidata; Q54904665
RX   PubMed=16049480;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Characteristics: Established from MDA231-TGL cell line after 3 passage in nude mice.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
CC   Derived from metastatic site: Pleural effusion.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_VR35 ! MDA231-TGL
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 23-09-21; Version: 13
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RX   PubMed=16049480; DOI=10.1038/nature03799;
RA   Minn A.J., Gupta G.P., Siegel P.M., Bos P.D., Shu W.-P., Giri D.D.,
RA   Viale A.J., Olshen A.B., Gerald W.L., Massague J.;
RT   "Genes that mediate breast cancer metastasis to lung.";
RL   Nature 436:518-524(2005).
//