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Cellosaurus PC-9/GR/WR (CVCL_DG27)

[Text version]
Cell line name PC-9/GR/WR
Accession CVCL_DG27
Resource Identification Initiative To cite this cell line use: PC-9/GR/WR (RRID:CVCL_DG27)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Selected for resistance to: ChEBI; CHEBI:61400; WZ4002.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=26980747; DOI=10.18632/oncotarget.8013
Park J.H., Choi Y.J., Kim S.Y., Lee J.-E., Sung K.J., Park S., Kim W.S., Song J.S., Choi C.-M., Sung Y.H., Rho J.K., Lee J.C.
Activation of the IGF1R pathway potentially mediates acquired resistance to mutant-selective 3rd-generation EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer.
Oncotarget 7:22005-22015(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DG27
Encyclopedic resources Wikidata; Q54938500
Entry history
Entry creation13-Jul-2016
Last entry update05-Oct-2023
Version number13