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Cellosaurus PC-9/GR/WR (CVCL_DG27)

[Text version]

Cell line name PC-9/GR/WR
Accession CVCL_DG27
Resource Identification Initiative To cite this cell line use: PC-9/GR/WR (RRID:CVCL_DG27)
Comments Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Selected for resistance to: ChEBI; CHEBI:61400; WZ4002.
Sequence variations EGFR p.Glu746_Ala750del (c.2235_2249del15) (from parent cell line).
Homozygous for TP53 p.Arg248Gln (c.743G>A) (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=26980747; DOI=10.18632/oncotarget.8013
Park J.H., Choi Y.J., Kim S.Y., Lee J.-E., Sung K.J., Park S., Kim W.S., Song J.S., Choi C.-M., Sung Y.H., Rho J.K., Lee J.C.
Activation of the IGF1R pathway potentially mediates acquired resistance to mutant-selective 3rd-generation EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer.
Oncotarget 7:22005-22015(2016)

Cross-references
Other Wikidata; Q54938500
Entry history
Entry creation13-Jul-2016
Last entry updated06-Sep-2019
Version number6