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Cellosaurus PC-9/WZR11 (CVCL_DG32)

[Text version]
Cell line name PC-9/WZR11
Synonyms WZR11
Accession CVCL_DG32
Resource Identification Initiative To cite this cell line use: PC-9/WZR11 (RRID:CVCL_DG32)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Selected for resistance to: ChEBI; CHEBI:61400; WZ4002.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_DH34 (PC-9/GR4)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=22961667; DOI=10.1158/2159-8290.CD-12-0103
Ercan D., Xu C.-X., Yanagita M., Monast C.S., Pratilas C.A., Montero J., Butaney M., Shimamura T., Sholl L.M., Ivanova E.V., Tadi M., Rogers A., Repellin C., Capelletti M., Maertens O., Goetz E.M., Letai A.G., Garraway L.A., Lazzara M.J., Rosen N., Gray N.S., Wong K.-K., Janne P.A.
Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.
Cancer Discov. 2:934-947(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DG32
Encyclopedic resources Wikidata; Q54938507
Gene expression databases GEO; GSM925741
Polymorphism and mutation databases Progenetix; CVCL_DG32
Entry history
Entry creation13-Jul-2016
Last entry update05-Oct-2023
Version number13