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Cellosaurus PC-9/GR4 (CVCL_DH34)

[Text version]

Cell line name PC-9/GR4
Synonyms PC-9 GR4; PC9GR4; GR4
Accession CVCL_DH34
Resource Identification Initiative To cite this cell line use: PC-9/GR4 (RRID:CVCL_DH34)
Comments Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Sequence variations EGFR p.Glu746_Ala750del (c.2235_2249del15) (from parent cell line).
Homozygous for TP53 p.Arg248Gln (c.743G>A) (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Children:
CVCL_DI33 (PC-9/DR1)CVCL_DI34 (PC-9/DR2)CVCL_DI35 (PC-9/DR3)
CVCL_DI36 (PC-9/DR4)CVCL_DI37 (PC-9/DR5)CVCL_DI38 (PC-9/DR6)
CVCL_DG30 (PC-9/WZR09)CVCL_DG31 (PC-9/WZR10)CVCL_DG32 (PC-9/WZR11)
CVCL_DG33 (PC-9/WZR12)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=20118985; DOI=10.1038/onc.2009.526
Ercan D., Zejnullahu K., Yonesaka K., Xiao Y., Capelletti M., Rogers A., Lifshits E., Brown A., Lee C., Christensen J.G., Kwiatkowski D.J., Engelman J.A., Janne P.A.
Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor.
Oncogene 29:2346-2356(2010)

PubMed=22961667; DOI=10.1158/2159-8290.CD-12-0103
Ercan D., Xu C., Yanagita M., Monast C.S., Pratilas C.A., Montero J., Butaney M., Shimamura T., Sholl L., Ivanova E.V., Tadi M., Rogers A., Repellin C., Capelletti M., Maertens O., Goetz E.M., Letai A., Garraway L.A., Lazzara M.J., Rosen N., Gray N.S., Wong K.-K., Janne P.A.
Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.
Cancer Discov. 2:934-947(2012)

Cross-references
Gene expression databases GEO; GSM925738
GEO; GSM481164
Other Wikidata; Q54938497
Entry history
Entry creation13-Jul-2016
Last entry updated06-Sep-2019
Version number6