Cell line name |
HT-29 BR100 |
Synonyms |
HT29 BR100; BR100 |
Accession |
CVCL_DH88 |
Resource Identification Initiative |
To cite this cell line use: HT-29 BR100 (RRID:CVCL_DH88) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI:52717; Bortezomib (Velcade). Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
Sequence variations |
- Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
Disease |
Colon adenocarcinoma (NCIt: C4349) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0320 (HT-29) |
Sex of cell |
Female |
Age at sampling |
44Y |
Category |
Cancer cell line |
Publications | PubMed=22216088; DOI=10.1371/journal.pone.0027996 Suzuki E., Demo S., Deu E., Keats J.J., Arastu-Kapur S., Bergsagel P.L., Bennett M.K., Kirk C.J. Molecular mechanisms of bortezomib resistant adenocarcinoma cells. PLoS ONE 6:E27996-E27996(2011) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_DH88
|
Encyclopedic resources |
Wikidata; Q54896509
|
Gene expression databases |
GEO; GSM736968
|
Polymorphism and mutation databases |
Progenetix; CVCL_DH88
|
Entry history |
Entry creation | 13-Jul-2016 |
Last entry update | 05-Oct-2023 |
Version number | 17 |
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