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Cellosaurus PC-9/GR2 (CVCL_DI29)

[Text version]
Cell line name PC-9/GR2
Synonyms PC-9 GR2
Accession CVCL_DI29
Resource Identification Initiative To cite this cell line use: PC-9/GR2 (RRID:CVCL_DI29)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=20118985; DOI=10.1038/onc.2009.526
Ercan D., Zejnullahu K., Yonesaka K., Xiao Y., Capelletti M., Rogers A., Lifshits E., Brown A., Lee C., Christensen J.G., Kwiatkowski D.J., Engelman J.A., Janne P.A.
Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor.
Oncogene 29:2346-2356(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DI29
Encyclopedic resources Wikidata; Q54938495
Gene expression databases GEO; GSM481162
Polymorphism and mutation databases Progenetix; CVCL_DI29
Entry history
Entry creation13-Jul-2016
Last entry update05-Oct-2023
Version number13