| Cell line name |
MCF7/MIII |
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| Synonyms |
MCF-7/MIII; MIII |
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| Accession |
CVCL_DP49 |
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| Resource Identification Initiative |
To cite this cell line use: MCF7/MIII (RRID:CVCL_DP49) |
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| Comments |
Population: Caucasian.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0031 (MCF-7)
Children:
|
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| Sex of cell |
Female |
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| Age at sampling |
69Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=8380254
Brunner N., Boulay V., Fojo A.T., Freter C.E., Lippman M.E., Clarke R.
Acquisition of hormone-independent growth in MCF-7 cells is accompanied by increased expression of estrogen-regulated genes but without detectable DNA amplifications.
Cancer Res. 53:283-290(1993) PubMed=8380760; DOI=10.1007/BF00880062
Thompson E.W., Brunner N., Torri J., Johnson M.D., Boulay V., Wright A., Lippman M.E., Steeg P.S., Clarke R.
The invasive and metastatic properties of hormone-independent but hormone-responsive variants of MCF-7 human breast cancer cells.
Clin. Exp. Metastasis 11:15-26(1993) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_DP49
|
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| Encyclopedic resources |
Wikidata; Q54904471
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| Entry history |
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| Entry creation | 13-Jul-2016 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 12 |
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