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Cellosaurus MCF7/MIII (CVCL_DP49)

[Text version]

Cell line name MCF7/MIII
Synonyms MCF-7/MIII; MIII
Accession CVCL_DP49
Resource Identification Initiative To cite this cell line use: MCF7/MIII (RRID:CVCL_DP49)
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

Brunner N., Boulay V., Fojo A.T., Freter C.E., Lippman M.E., Clarke R.
Acquisition of hormone-independent growth in MCF-7 cells is accompanied by increased expression of estrogen-regulated genes but without detectable DNA amplifications.
Cancer Res. 53:283-290(1993)

PubMed=8380760; DOI=10.1007/BF00880062
Thompson E.W., Brunner N., Torri J., Johnson M.D., Boulay V., Wright A., Lippman M.E., Steeg P.S., Clarke R.
The invasive and metastatic properties of hormone-independent but hormone-responsive variants of MCF-7 human breast cancer cells.
Clin. Exp. Metastasis 11:15-26(1993)

Other Wikidata; Q54904471
Entry history
Entry creation13-Jul-2016
Last entry update02-Jul-2020
Version number6