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Cellosaurus MCF7/LCC2 (CVCL_DP51)

[Text version]
Cell line name MCF7/LCC2
Synonyms MCF-7/LCC-2; MCF-7/LCC2; MCF-7-LCC2; LCC2
Accession CVCL_DP51
Resource Identification Initiative To cite this cell line use: MCF7/LCC2 (RRID:CVCL_DP51)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:44616; Afimoxifene (4-hydroxytamoxifen; 4-OH TAM).
Omics: Proteome analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_DP50 (MCF7/LCC1)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=8324732
Brunner N., Frandsen T.L., Holst-Hansen C., Bei M., Thompson E.W., Wakeling A.E., Lippman M.E., Clarke R.
MCF7/LCC2: a 4-hydroxytamoxifen resistant human breast cancer variant that retains sensitivity to the steroidal antiestrogen ICI 182,780.
Cancer Res. 53:3229-3232(1993)

PubMed=11078910; DOI=10.1016/S0304-3835(00)00579-6
Lilling G., Hacohen H., Nordenberg J., Livnat T., Rotter V., Sidi Y.
Differential sensitivity of MCF-7 and LCC2 cells, to multiple growth inhibitory agents: possible relation to high bcl-2/bax ratio?
Cancer Lett. 161:27-34(2000)

PubMed=23868472; DOI=10.1038/ncomms3175
Johansson H.J., Sanchez B.C., Mundt F., Forshed J., Kovacs A., Panizza E., Hultin-Rosenberg L., Lundgren B., Martens U., Mathe G., Yakhini Z., Helou K., Krawiec K., Kanter L., Hjerpe A., Stal O., Linderholm B.K., Lehtio J.
Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer.
Nat. Commun. 4:2175.1-2175.10(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DP51
Encyclopedic resources Wikidata; Q54904469
Proteomic databases PRIDE; PXD000281
Entry history
Entry creation13-Jul-2016
Last entry update05-Oct-2023
Version number12