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Cellosaurus LAMA84-r (CVCL_DP57)

[Text version]
Cell line name LAMA84-r
Accession CVCL_DP57
Resource Identification Initiative To cite this cell line use: LAMA84-r (RRID:CVCL_DP57)
Comments Selected for resistance to: ChEBI; CHEBI:45783; Imatinib (Gleevec; STI571).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Lys319Ter (c.955A>T); Zygosity=Homozygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0388 (LAMA-84)
Sex of cell Female
Age at sampling 29Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO11,12
D5S81811,12
D7S82011
D13S31711,12
D16S53911
TH017
TPOX10
vWA14,17

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Publications

PubMed=10910924; DOI=10.1182/blood.V96.3.1070
Mahon F.-X., Deininger M.W.N., Schultheis B., Chabrol J., Reiffers J., Goldman J.M., Vaz de Melo J.
Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance.
Blood 96:1070-1079(2000)

Cross-references
Cell line collections (Providers) ATCC; CRL-3348
Encyclopedic resources Wikidata; Q54901917
Entry history
Entry creation13-Jul-2016
Last entry update29-Jun-2023
Version number12