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Cellosaurus KCL22-r (CVCL_DP58)

[Text version]

Cell line name KCL22-r
Synonyms KCL22R
Accession CVCL_DP58
Resource Identification Initiative To cite this cell line use: KCL22-r (RRID:CVCL_DP58)
Comments Selected for resistance to: ChEBI; CHEBI:45783; Imatinib (Gleevec; STI571).
Omics: Proteome analysis by 2D-DE/MS.
Derived from sampling site: Pleural effusion.
Sequence variations BCR-ABL1 gene fusion (from parent cell line).
TP53 p.Pro301fs (c.901delC) (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2091 (KCL-22)
Sex of cell Female
Age at sampling 32Y
Category Cancer cell line

PubMed=10910924; DOI=10.1182/blood.V96.3.1070
Mahon F.-X., Deininger M.W.N., Schultheis B., Chabrol J., Reiffers J., Goldman J.M., Melo J.V.
Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance.
Blood 96:1070-1079(2000)

PubMed=20417730; DOI=10.1016/j.bbapap.2010.04.009
Colavita I., Esposito N., Martinelli R., Catanzano F., Melo J.V., Pane F., Ruoppolo M., Salvatore F.
Gaining insights into the Bcr-Abl activity-independent mechanisms of resistance to imatinib mesylate in KCL22 cells: a comparative proteomic approach.
Biochim. Biophys. Acta 1804:1974-1987(2010)

PubMed=23754495; DOI=10.1002/pmic.201200444
Colavita I., Esposito N., Quintarelli C., Nigro E., Pane F., Ruoppolo M., Salvatore F.
Identification of annexin A1 interacting proteins in chronic myeloid leukemia KCL22 cells.
Proteomics 13:2414-2418(2013)

Other Wikidata; Q54899693
Proteomic databases PRIDE; PXD000030
Entry history
Entry creation13-Jul-2016
Last entry update12-Mar-2020
Version number5