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Cellosaurus MCF-7/Twist (CVCL_DR99)

[Text version]
Cell line name MCF-7/Twist
Accession CVCL_DR99
Resource Identification Initiative To cite this cell line use: MCF-7/Twist (RRID:CVCL_DR99)
Comments Population: Caucasian.
Transfected with: HGNC; 12428; TWIST1.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=16322226; DOI=10.1158/0008-5472.CAN-05-0712
Mironchik Y., Winnard P.T. Jr., Vesuna F., Kato Y., Wildes F., Pathak A.P., Kominsky S.L., Artemov D., Bhujwalla Z., Van Diest P., Burger H., Glackin C., Raman V.
Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer.
Cancer Res. 65:10801-10809(2005)

PubMed=20019840; DOI=10.1593/neo.91084
Vesuna F., Lisok A., Kimble B., Raman V.
Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression.
Neoplasia 11:1318-1328(2009)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DR99
Encyclopedic resources Wikidata; Q54904396
Entry history
Entry creation13-Jul-2016
Last entry update05-Oct-2023
Version number12