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Cellosaurus Huh-7.5.1 (CVCL_E049)

[Text version]

Cell line name Huh-7.5.1
Synonyms Huh 7.5.1; Huh7.5.1
Accession CVCL_E049
Resource Identification Initiative To cite this cell line use: Huh-7.5.1 (RRID:CVCL_E049)
Comments Population: Japanese.
Characteristics: Compared to the parent Huh-7 cell line, permits improved HCV production when infected with strain JFH-1.
Sequence variations Mutation; HGNC; 19102; DDX58; Simple; p.Thr55Ile (c.164C>T); Zygosity=Unspecified (from parent cell line).
Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7927 (Huh-7.5)
Children:
CVCL_YU21 (Huh7.5.1-5)CVCL_YU20 (Huh7.5.1-8)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
Publications

PubMed=15939869; DOI=10.1073/pnas.0503596102
Zhong J., Gastaminza P., Cheng G.-F., Kapadia S., Kato T., Burton D.R., Wieland S.F., Uprichard S.L., Wakita T., Chisari F.V.
Robust hepatitis C virus infection in vitro.
Proc. Natl. Acad. Sci. U.S.A. 102:9294-9299(2005)

PubMed=23285155; DOI=10.1371/journal.pone.0052697
Murayama A., Sugiyama N., Yoshimura S., Ishihara-Sugano M., Masaki T., Kim S., Wakita T., Mishiro S., Kato T.
A subclone of HuH-7 with enhanced intracellular hepatitis C virus production and evasion of virus related-cell cycle arrest.
PLoS ONE 7:E52697-E52697(2012)

PubMed=25420655; DOI=10.7883/yoken.JJID.2014.231
Shirasago Y., Sekizuka T., Saito K., Suzuki T., Wakita T., Hanada K., Kuroda M., Abe R., Fukasawa M.
Isolation and characterization of an Huh.7.5.1-derived cell clone highly permissive to hepatitis C virus.
Jpn. J. Infect. Dis. 68:81-88(2015)

Cross-references
Cell line collections CCTCC; GDC0137
Ontologies BTO; BTO:0005463
Other Wikidata; Q54896857
Entry history
Entry creation22-Oct-2012
Last entry update23-Sep-2021
Version number18