ID   Huh-7.5.1
AC   CVCL_E049
SY   Huh 7.5.1; Huh7.5.1
DR   BTO; BTO:0005463
DR   BioGRID_ORCS_Cell_line; 735
DR   cancercelllines; CVCL_E049
DR   CCTCC; GDC0137
DR   ChEMBL-Cells; CHEMBL4483152
DR   ChEMBL-Targets; CHEMBL4483247
DR   PubChem_Cell_line; CVCL_E049
DR   Wikidata; Q54896857
RX   PubMed=15939869;
RX   PubMed=23285155;
RX   PubMed=25420655;
CC   Population: Japanese.
CC   Virology: Compared to the parent Huh-7 cell line, permits improved hepatitis C virus (HCV) production when infected with strain JFH-1.
CC   Sequence variation: Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 19102; RIGI; Simple; p.Thr55Ile (c.164C>T); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_7927 ! Huh-7.5
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 30-01-24; Version: 23
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RX   PubMed=15939869; DOI=10.1073/pnas.0503596102;
RA   Zhong J., Gastaminza P., Cheng G.-F., Kapadia S., Kato T., Burton D.R.,
RA   Wieland S.F., Uprichard S.L., Wakita T., Chisari F.V.;
RT   "Robust hepatitis C virus infection in vitro.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:9294-9299(2005).
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RX   PubMed=23285155; DOI=10.1371/journal.pone.0052697;
RA   Murayama A., Sugiyama N., Yoshimura S., Ishihara-Sugano M., Masaki T.,
RA   Kim S., Wakita T., Mishiro S., Kato T.;
RT   "A subclone of HuH-7 with enhanced intracellular hepatitis C virus
RT   production and evasion of virus related-cell cycle arrest.";
RL   PLoS ONE 7:E52697-E52697(2012).
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RX   PubMed=25420655; DOI=10.7883/yoken.JJID.2014.231;
RA   Shirasago Y., Sekizuka T., Saito K., Suzuki T., Wakita T., Hanada K.,
RA   Kuroda M., Abe R., Fukasawa M.;
RT   "Isolation and characterization of an Huh.7.5.1-derived cell clone
RT   highly permissive to hepatitis C virus.";
RL   Jpn. J. Infect. Dis. 68:81-88(2015).
//