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Cellosaurus W-V (CVCL_E079)

[Text version]
Cell line name W-V
Synonyms WV1
Accession CVCL_E079
Resource Identification Initiative To cite this cell line use: W-V (RRID:CVCL_E079)
Comments Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; 12791; WRN; Simple; p.Lys924fs*973 (c.2773delG); Zygosity=Unspecified (PubMed=9230208).
Disease Werner syndrome (NCIt: C3447)
Werner syndrome (ORDO: Orphanet_902)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 45Y
Category Transformed cell line
STR profile Source(s): RCB

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81811,12
D7S8209,10
D13S3178,13
D16S5399
TH019
TPOX8
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=2878433; DOI=10.1098/rspb.1986.0070
Huschtscha L.I., Thompson K.V.A., Holliday R.
The susceptibility of Werner's syndrome and other human skin fibroblasts to SV40-induced transformation and immortalization.
Proc. R. Soc. Lond. B. Biol. Sci. 229:1-12(1986)

PubMed=2762303; DOI=10.1073/pnas.86.15.5893
Fukuchi K.-i., Martin G.M., Monnat R.J. Jr.
Mutator phenotype of Werner syndrome is characterized by extensive deletions.
Proc. Natl. Acad. Sci. U.S.A. 86:5893-5897(1989)

PubMed=9230208
Bennett S.E., Umar A., Oshima J., Monnat R.J. Jr., Kunkel T.A.
Mismatch repair in extracts of Werner syndrome cell lines.
Cancer Res. 57:2956-2960(1997)

CLPUB00712
Henson J.D.
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006), University of Sydney, Australia

PubMed=19935656; DOI=10.1038/nbt.1587
Henson J.D., Cao Y., Huschtscha L.I., Chang A.C.-M., Au A.Y.M., Pickett H.A., Reddel R.R.
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

PubMed=22989712; DOI=10.1093/nar/gks862
Mendez-Bermudez A., Hidalgo-Bravo A., Cotton V.E., Gravani A., Jeyapalan J.N., Royle N.J.
The roles of WRN and BLM RecQ helicases in the alternative lengthening of telomeres.
Nucleic Acids Res. 40:10809-10820(2012)

Cross-references
Cell line collections (Providers) RCB; RCB0252
Cell line databases/resources CLO; CLO_0050644
Biological sample resources BioSample; SAMN03472349
Encyclopedic resources Wikidata; Q54993450
Entry history
Entry creation22-Oct-2012
Last entry update29-Jun-2023
Version number18