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Cellosaurus LP-9 (CVCL_E109)

[Text version]

Cell line name LP-9
Synonyms LP9; AG07086; AG07086A
Accession CVCL_E109
Resource Identification Initiative To cite this cell line use: LP-9 (RRID:CVCL_E109)
Comments Characteristics: Senesces at ~50-60 PDL (PubMed=6192933; PubMed=10648628).
Derived from sampling site: Ascites; mesothelial cells.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E108 (LP9/TERT-1)
Sex of cell Female
Age at sampling 26Y
Category Finite cell line
Web pages http://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf

PubMed=6186388; DOI=10.1016/0092-8674(82)90324-5
Wu Y.-J., Parker L.M., Binder N.E., Beckett M.A., Sinard J.H., Griffiths C.T., Rheinwald J.G.
The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia.
Cell 31:693-703(1982)

PubMed=6192933; DOI=10.1016/0092-8674(83)90155-1
Connell N.D., Rheinwald J.G.
Regulation of the cytoskeleton in mesothelial cells: reversible loss of keratin and increase in vimentin during rapid growth in culture.
Cell 34:245-253(1983)

Tubo R.A., Rheinwald J.G.
Normal human mesothelial cells and fibroblasts transfected with the EJras oncogene become EGF-independent, but are not malignantly transformed.
Oncogene Res. 1:407-421(1987)

PubMed=9382953; DOI=10.1089/hum.1997.8.16-1867
Murphy J.-E., Rheinwald J.G.
Intraperitoneal injection of genetically modified, human mesothelial cells for systemic gene therapy.
Hum. Gene Ther. 8:1867-1879(1997)

PubMed=10648628; DOI=10.1128/MCB.20.4.1436-1447.2000
Dickson M.A., Hahn W.C., Ino Y., Ronfard V., Wu J.Y., Weinberg R.A., Louis D.N., Li F.P., Rheinwald J.G.
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Mol. Cell. Biol. 20:1436-1447(2000)

PubMed=19489101; DOI=10.1002/stem.64
Dabelsteen S., Hercule P., Barron P., Rice M., Dorsainville G., Rheinwald J.G.
Epithelial cells derived from human embryonic stem cells display p16INK4A senescence, hypermotility, and differentiation properties shared by many P63+ somatic cell types.
Stem Cells 27:1388-1399(2009)

Cell line collections Coriell; AG07086
Ontologies CLO; CLO_0035653
Other Wikidata; Q54902913
Entry history
Entry creation22-Oct-2012
Last entry update02-Jul-2020
Version number9