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Cellosaurus UD-SCC-2 (CVCL_E325)

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Cell line name UD-SCC-2
Synonyms UD-SCC 2; UD-SCC2; UDSCC2; University of Dusseldorf-Squamous Cell Carcinoma-2
Accession CVCL_E325
Resource Identification Initiative To cite this cell line use: UD-SCC-2 (RRID:CVCL_E325)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: OPC-22 oral and pharyngeal cancer cell line panel.
Characteristics: Contains from 14 to 23 copies of the HPV16 genome.
Doubling time: 42 hours (PubMed=10628319); 4.1 days (PubMed=29156801).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: Genome sequenced (low read coverage).
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Sequence variations Homozygous for KMT2D p.Arg5154Gln (c.15461G>A) (PubMed=31541927).
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.2
Native American0
East Asian, North4
East Asian, South0
South Asian0
European, North57.49
European, South35.31
Disease Hypopharyngeal squamous cell carcinoma (NCIt: C4043)
Squamous cell carcinoma of the hypopharynx (ORDO: Orphanet_494547)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): PubMed=25275298; PubMed=29156801

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135814,16
D5S81810,11
D7S8208,9
D8S117913,15
D13S3178
D16S53911,13
D18S5112,17
D21S1130,31.2
FGA20,27
Penta D9,13
Penta E10
TH018,9
TPOX8,10
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=10628319
Ballo H., Koldovsky P., Hoffmann T.K., Balz V., Hildebrandt B., Gerharz C.-D., Bier H.
Establishment and characterization of four cell lines derived from human head and neck squamous cell carcinomas for an autologous tumor-fibroblast in vitro model.
Anticancer Res. 19:3827-3836(1999)

PubMed=15495191; DOI=10.1002/gcc.20119
Raschke S., Balz V., Efferth T., Schulz W.A., Florl A.R.
Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines.
Genes Chromosomes Cancer 42:58-67(2005)

PubMed=16331601; DOI=10.1002/ijc.21514
Muller A., Sonkoly E., Eulert C., Gerber P.A., Kubitza R., Schirlau K., Franken-Kunkel P., Poremba C., Snyderman C., Klotz L.-O., Ruzicka T., Bier H., Zlotnik A., Whiteside T.L., Homey B., Hoffmann T.K.
Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy.
Int. J. Cancer 118:2147-2157(2006)

PubMed=18487078; DOI=10.1016/j.oraloncology.2008.02.006
Hoffmann T.K., Sonkoly E., Hauser U., van Lierop A., Whiteside T.L., Klussmann J.P., Hafner D., Schuler P., Friebe-Hoffmann U., Scheckenbach K., Erjala K., Grenman R., Schipper J., Bier H., Balz V.
Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma.
Oral Oncol. 44:1100-1109(2008)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24201445; DOI=10.1101/gr.164806.113
Akagi K., Li J., Broutian T.R., Padilla-Nash H.M., Xiao W., Jiang B., Rocco J.W., Teknos T.N., Kumar B., Wangsa D., He D., Ried T., Symer D.E., Gillison M.L.
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
Genome Res. 24:185-199(2014)

PubMed=25275298; DOI=10.18632/oncotarget.2417
Martin D., Abba M.C., Molinolo A.A., Vitale-Cross L., Wang Z., Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Oncotarget 5:8906-8923(2014)

PubMed=28236344; DOI=10.1002/hed.24729
Walline H.M., Goudsmit C.M., McHugh J.B., Tang A.L., Owen J.H., Teh B.T., McKean E., Glover T.W., Graham M.P., Prince M.E., Chepeha D.B., Chinn S.B., Ferris R.L., Gollin S.M., Hoffmann T.K., Bier H., Brakenhoff R., Bradford C.R., Carey T.E.
Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines.
Head Neck 39:840-852(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S., Shen L., Sambandam V., Rao X., Xi Y., Li L., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004
van Harten A.M., Poell J.B., Buijze M., Brink A., Wells S.I., Rene Leemans C., Wolthuis R.M.F., Brakenhoff R.H.
Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.
Oral Oncol. 98:53-61(2019)

Cross-references
Cell line databases/resources CCLE; UDSCC2_UPPER_AERODIGESTIVE_TRACT
Cell_Model_Passport; SIDM00025
Cosmic-CLP; 1299073
DepMap; ACH-002391
Chemistry resources GDSC; 1299073
PharmacoDB; UDSCC2_1638_2019
Other Wikidata; Q54990107
Polymorphism and mutation databases Cosmic; 932282
Cosmic; 2296311
Entry history
Entry creation22-Oct-2012
Last entry update12-Mar-2020
Version number17