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Cellosaurus UD-SCC-2 (CVCL_E325)

Cell line name UD-SCC-2
Synonyms UD-SCC 2; UD-SCC2; UDSCC2
Accession CVCL_E325
Resource Identification Initiative To cite this cell line use: UD-SCC-2 (RRID:CVCL_E325)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: OPC-22 oral and pharyngeal cancer cell line panel.
Characteristics: Contains from 14 to 23 copies of the HPV16 genome.
Doubling time: 42 hours (PubMed=10628319); 4.1 days (PubMed=29156801).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Disease Hypopharyngeal squamous cell carcinoma (NCIt: C4043)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): PubMed=25275298; PubMed=29156801

Penta D9,13
Penta E10

Ballo H., Koldovsky P., Hoffmann T.K., Balz V., Hildebrandt B., Gerharz C.-D., Bier H.
Establishment and characterization of four cell lines derived from human head and neck squamous cell carcinomas for an autologous tumor-fibroblast in vitro model.
Anticancer Res. 19:3827-3836(1999)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24201445; DOI=10.1101/gr.164806.113
Akagi K., Li J., Broutian T.R., Padilla-Nash H., Xiao W., Jiang B., Rocco J.W., Teknos T.N., Kumar B., Wangsa D., He D., Ried T., Symer D.E., Gillison M.L.
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
Genome Res. 24:185-199(2014)

PubMed=25275298; DOI=10.18632/oncotarget.2417
Martin D., Abba M.C., Molinolo A.A., Vitale-Cross L., Wang Z., Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Oncotarget 5:8906-8923(2014)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S., Shen L., Sambandam V., Rao X., Xi Y., Li L., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cell line databases/resources CCLE; UDSCC2_UPPER_AERODIGESTIVE_TRACT
Cosmic-CLP; 1299073
GDSC; 1299073
Other Wikidata; Q54990107
Polymorphism and mutation databases Cosmic; 932282
Cosmic; 2296311